The time required for the concentration of a substance in the body to decrease by half. Determines dosing frequency and accumulation patterns.
"Half-Life" is filed under Pharmacology in the PeptideAtlas glossary, alongside 29 other terms in that group.
The term applies directly to 89 compound profiles here: BPC-157 (evidence C), TB-500 (evidence D), Semaglutide (evidence A), Tirzepatide (evidence A), PT-141 (evidence A), Ipamorelin (evidence D), CJC-1295 (evidence D), Sermorelin (evidence C), and others. Each profile states the strength of the human evidence rather than only what the compound is claimed to do.
5 other glossary entries refer to this term in their own definition, which is usually the fastest way to see how it is used in practice.
A modified version of a naturally occurring peptide, engineered to improve stability, bioavailability, potency, or half-life. Semaglutide is an analogue of GLP-1.
A chemical modification that joins the ends of a peptide chain into a ring, improving stability and resistance to enzymatic breakdown. Many therapeutic peptides use cyclization to extend their half-life.
The attachment of polyethylene glycol (PEG) chains to a peptide, increasing its molecular size, reducing kidney clearance, and extending its half-life. PEG-MGF is an example.
The proportion of a substance that enters the circulation when introduced into the body and is able to have an active effect. Different administration routes affect bioavailability.
Compounds where this applies: BPC-157, TB-500, Semaglutide, Tirzepatide, PT-141, Ipamorelin, CJC-1295, Sermorelin, Tesamorelin, GHRP-6, Thymosin Alpha-1, Selank, Semax, DSIP, MK-677, Liraglutide, Cagrilintide, ARA-290 (Cibinetide), PEG-MGF, Follistatin 344.
Terms that reference this one: Analogue, Cyclization, PEGylation, Acylation, DAC (Drug Affinity Complex).
More Pharmacology terms: Bioavailability, Pharmacokinetics, Pharmacodynamics, First-Pass Metabolism, Receptor Agonist, Receptor Antagonist, Desensitization, Tachyphylaxis, Downregulation, GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), Glucagon, Amylin, Ghrelin, Growth Hormone Secretagogue (GHS), GHRP (Growth Hormone Releasing Peptide), GHRH (Growth Hormone Releasing Hormone), GHS-R1a (Growth Hormone Secretagogue Receptor), Secretagogue, Melanocortin Receptor.