BPC-157 is a synthetic 15-amino-acid peptide (sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, MW ~1419.5 g/mol) derived from a protein found in human gastric juice. It has demonstrated robust regenerative and cytoprotective effects across hundreds of animal studies spanning tendon, ligament, muscle, bone, nerve, GI tract, and blood vessel healing. However, human clinical data is extremely limited — only three pilot studies have examined BPC-157 in humans as of 2025 (knee pain n=16, interstitial cystitis n=12, IV safety n=2). The FDA classifies it as Category 2, prohibiting compounding, and WADA bans its use in sports.
76 vendors tracked by PeptideAtlas list BPC-157, priced from $20.00 to $700. The lowest price per milligram is $1.38/mg at Buy Peptides Australia (50 mg). 50 independent Janoshik purity tests cover BPC-157 across 34 vendors. Results range from 96.9% to 99.9%.
Category: Healing & Recovery. Evidence rating: C (early/mixed human evidence).
Clinical status: Research-only / No approved human indication. Phase I oral safety trial completed; Phase II UC trial underway.
BPC-157 acts through multiple overlapping pathways. It promotes angiogenesis by upregulating VEGFR2 and VEGF expression, and activates nitric oxide synthesis via the Src kinase-caveolin-1 pathway and Akt-eNOS axis. It engages ERK1/2 signaling, activating c-Fos, c-Jun, and EGR-1 transcription…
Research base: 3 registered clinical trials and 106 indexed publications reference BPC-157.
Safety considerations: No completed randomized controlled human clinical trials for safety assessment; Preclinical safety studies across multiple species found no toxic or lethal dose thresholds at ranges from 6 mcg/kg to 20 mg/kg; LD1 not achieved; no teratogenic, genotoxic, or anaphylactic effects in necropsy/histopathology; FDA previously classified BPC-157 as Category 2 (significant safety concerns); removed from Category 2 on April 15, 2026. PCAC review pending July 2026 to determine compounding eligibility. FDA noted insufficient human safety data and potential immunogenicity risks.
Reviewed by the PeptideAtlas Editorial Team.
| Amino-acid sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (GEPPPGKPADDAGLV) |
|---|---|
| Molecular formula | C62H98N16O22 |
| Molecular weight | ~1419.5 g/mol |
| Half-life | ~15 min IV (animal data); oral activity persists 24+ hours |
| Bioavailability | IM: 15-19% (rats), 45-51% (dogs); resistant to stomach acid degradation |
| Production method | synthetic |
| Anti-doping status | Prohibited in sport (WADA) |
| US regulatory status | Not FDA-approved. Removed from Category 2 on April 15, 2026 after HHS Secretary Kennedy directed withdrawal of nominations. PCAC review scheduled July 23-24, 2026 to determine compounding eligibility. Previously prohibited from compounding under Category 2… |
| Vendor | Size | Price | Price per mg |
|---|---|---|---|
| Buy Peptides Australia | 50 mg | $69.00 | $1.38/mg |
| Alpha Grade Peptides | 70mg | $110 | $1.57/mg |
| Ameano Peptides | 50mg | $88.00 | $1.76/mg |
| Wholesale Peptide | 70mg | $136 | $1.94/mg |
| Fusion Peptides | 50mg | $100 | $2.00/mg |
| PureRx Peptides | 10mg | $23.00 | $2.30/mg |
| Peptide Labs | 20mg | $49.99 | $2.50/mg |
| All Peptides USA | 10mg | $29.00 | $2.90/mg |
| Choice Peps | 10MG | $30.00 | $3.00/mg |
| Huaian Hanyou Peptide | 70mg | $220 | $3.14/mg |
| Guangzhou Jeep Biotechnology JEEP | 70mg | $220 | $3.14/mg |
| protopeptide.is | 10mg | $33.00 | $3.30/mg |
| Ascension Peptides | 50mg | $175 | $3.50/mg |
| Evolve BioPep | 10mg | $35.00 | $3.50/mg |
| Prospera Peptides | 10mg | $35.00 | $3.50/mg |
| Purus Peptides | 10MG | $37.00 | $3.70/mg |
| Legendary Peptides | 10mg | $38.00 | $3.80/mg |
| Disguised Research Peptides | 50MG | $200 | $4.00/mg |
| M-Peptides | 50mg | $200 | $4.00/mg |
| Great Lakes Peptides | 5mg | $20.00 | $4.00/mg |
| AstropeptidesUSA | 10 mg | $40.00 | $4.00/mg |
| BioPep Store | 5.15mg | $21.00 | $4.08/mg |
| Prime Source | 70mg | $300 | $4.29/mg |
| Athena Peptides | 10MG | $44.00 | $4.40/mg |
| Precision Peptide Co | 10mg | $44.00 | $4.40/mg |
| Vendor | Best tested purity |
|---|---|
| Peptira | 99.9% |
| Qingdao Sigma Chemical QSC | 99.9% |
| cellpept | 99.9% |
| Henan Sahe Peptide | 99.9% |
| HPR | 99.9% |
| MOB Peptides | 99.8% |
| Oasis Labs | 99.8% |
| PACIFIC WAVE PEPTIDES | 99.8% |
| Peptide Gurus | 99.8% |
| Amino Lair | 99.8% |
| Prime Peptides | 99.8% |
| New Wave Peptides Ltd | 99.8% |
| XTP | 99.8% |
| lilipetide | 99.8% |
| Cocer Peptides | 99.8% |
| Inno Peptides | 99.7% |
| Peptide Crafters | 99.7% |
| Pacific Wave | 99.7% |
| HK Peptides | 99.6% |
| Polaris Peptides | 99.6% |
| PeptiAtlas | 99.5% |
| liuquanqun | 99.5% |
| Kensingtonlabs.co | 99.5% |
| [email protected] | 99.5% |
| Modern Peptides | 99.5% |
Related peptides: TB-500, Thymosin Beta-4, Larazotide.
Compare: BPC-157 vs TB-500.
No. BPC-157 has no FDA approval for any indication. It was previously classified as Category 2 (prohibited from compounding), but on April 15, 2026, the FDA removed BPC-157 from Category 2 after HHS Secretary Kennedy directed withdrawal of the nominations. The PCAC is scheduled to review compounding eligibility at its July 23-24, 2026 meeting. Removal from Category 2 does not mean FDA approval —…
No. BPC-157 is a synthetic 15-amino-acid fragment (sequence: GEPPPGKPADDAGLV) of a larger protein found in gastric juice. It does not occur naturally in this isolated form.
The NCT02637284 trial examined oral BPC-157 (PCO-02/Bepecin) safety and pharmacokinetics in 42 healthy volunteers using single doses of 1-6 mg and repeated dosing of 3 mg TID for two weeks. A Phase II UC trial is underway. Only three pilot studies have tested BPC-157 in humans. No completed, published controlled efficacy trials exist.
Yes. WADA prohibits all growth factors and peptides not approved for human therapeutic use, including BPC-157, both in and out of competition.
In rats and dogs, approximately 15 minutes after IV administration. It undergoes rapid hepatic metabolism into peptide fragments and amino acids (primarily proline). However, it is uniquely resistant to stomach acid and may remain active 24+ hours after oral administration.
Vendors with independent lab tests for it: Eros Peptides, Pink Pony Peptides, HPR, Oasis Labs, Optima Chemical Supplies Inc, AstropeptidesUSA, Qingdao Sigma Chemical QSC.
Vendors stocking it: Direct Peptides UK, SwissChems, Limitless Life Nootropics, LimitlessBioChem, Polar Peptides, Purity Peptides, OP Labs, Risynth Bio, Mod Peptide, Uniting Wellness, Panda Peptides, PureRawz, NUPEPS Peptides, Eternal Peptides, M-Peptides, Amino Lair, Reta-Peptide, Oasis Peptides, Hangzhou Mandy Biotechnology, Zztai Peptide, Evolve BioPep, Nexaph, Wuhan Wansheng Biotechnology, Pura Peptides, Wolverine Peptides, Homopeptide, Pepix Labs, Peptide Origin, All Peptides USA, Million Pharm, China Peptides Supplier, DH Peps, Sigma Peptides, Biomax Research, NovaPeptide, Ultima Pharmaceuticals, Ameano Peptides, Mei Peptide, Fusion Peptides, MODPeptides.
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Independent lab results for BPC-157: Bpc157 10mg — Independent Lab Test Results, Bpc-157 - 5mg — Independent Lab Test Results, BPC 157 — Independent Lab Test Results.