A peptide hormone produced by the alpha cells of the pancreas that raises blood glucose levels by stimulating glycogenolysis and gluconeogenesis. Also increases energy expenditure. Dual GLP-1/glucagon agonists like survodutide combine appetite suppression with metabolic activation.
"Glucagon" is filed under Pharmacology in the PeptideAtlas glossary, alongside 29 other terms in that group.
The term applies directly to 22 compound profiles here: Semaglutide (evidence A), Tirzepatide (evidence A), Retatrutide (evidence B), Liraglutide (evidence A), Cagrilintide (evidence B), Survodutide (evidence B), Exenatide (evidence A), Dulaglutide (evidence A), and others. Each profile states the strength of the human evidence rather than only what the compound is claimed to do.
3 other glossary entries refer to this term in their own definition, which is usually the fastest way to see how it is used in practice.
An incretin hormone that stimulates insulin secretion, inhibits glucagon release, slows gastric emptying, and reduces appetite. GLP-1 receptor agonists like semaglutide mimic this hormone.
An incretin hormone that, like GLP-1, stimulates insulin secretion. Tirzepatide is a dual GLP-1/GIP agonist, and retatrutide is a triple GLP-1/GIP/glucagon agonist.
A peptide hormone co-secreted with insulin by pancreatic beta cells. It slows gastric emptying, suppresses glucagon secretion, and promotes satiety. Pramlintide is a synthetic amylin analogue; cagrilintide is a long-acting acylated amylin analogue used for weight management.
The proportion of a substance that enters the circulation when introduced into the body and is able to have an active effect. Different administration routes affect bioavailability.
Compounds where this applies: Semaglutide, Tirzepatide, Retatrutide, Liraglutide, Cagrilintide, Survodutide, Exenatide, Dulaglutide, Lixisenatide, Albiglutide, Pramlintide, Amylin, Mazdutide, Pemvidutide, Cotadutide, Danuglipron, Orforglipron, Octreotide, Somatostatin, Glucagon.
Terms that reference this one: GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), Amylin.
More Pharmacology terms: Bioavailability, Half-Life, Pharmacokinetics, Pharmacodynamics, First-Pass Metabolism, Receptor Agonist, Receptor Antagonist, Desensitization, Tachyphylaxis, Downregulation, GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), Amylin, Ghrelin, Growth Hormone Secretagogue (GHS), GHRP (Growth Hormone Releasing Peptide), GHRH (Growth Hormone Releasing Hormone), GHS-R1a (Growth Hormone Secretagogue Receptor), Secretagogue, Melanocortin Receptor.