Cagrilintide is a long-acting synthetic analog of human amylin, a peptide hormone co-secreted with insulin by pancreatic beta cells. It is being developed by Novo Nordisk both as a standalone agent and in fixed-dose combination with semaglutide (CagriSema). The CagriSema combination targets complementary appetite pathways — amylin acts on hindbrain satiety circuits while GLP-1 acts on hypothalamic and gut pathways. In the REDEFINE Phase 3 program, CagriSema achieved 20.4% weight loss at 68 weeks. Novo Nordisk filed for FDA approval in 2026.
32 vendors tracked by PeptideAtlas list Cagrilintide, priced from $25.00 to $295. The lowest price per milligram is $5.00/mg at Prospera Peptides (5mg). 20 independent Janoshik purity tests cover Cagrilintide across 16 vendors. Results range from 99.1% to 100.0%.
Category: Metabolic / Amylin Analog. Evidence rating: B (meaningful human data).
Clinical status: Phase 3 (REDEFINE program). NDA filed with FDA in 2026 for CagriSema.
Cagrilintide activates amylin receptors (calcitonin receptor + RAMP complexes) in the area postrema and other hindbrain regions, promoting meal-related satiety through distinct pathways from GLP-1 agonism. It slows gastric emptying, suppresses inappropriate glucagon release, and activates central…
Research base: 43 registered clinical trials and 44 indexed publications reference Cagrilintide.
Safety considerations: GI adverse events: 79.6% in CagriSema group vs 39.9% placebo (nausea, vomiting, diarrhea, constipation); GI events mainly transient and mild-to-moderate; Similar safety profile to GLP-1 class: pancreatitis risk, gallbladder events, thyroid C-cell tumors in rodents.
Reviewed by the PeptideAtlas Editorial Team.
| Half-life | ~7 days (allows once-weekly dosing) |
|---|---|
| Bioavailability | SC injection |
| Production method | synthetic |
| Anti-doping status | not-listed |
| US regulatory status | Not yet FDA-approved. NDA filed by Novo Nordisk in 2026 for CagriSema (cagrilintide + semaglutide) for chronic weight management. FDA review expected 2026-2027. |
| Vendor | Size | Price | Price per mg |
|---|---|---|---|
| Prospera Peptides | 5mg | $25.00 | $5.00/mg |
| All Peptides USA | 10 mg | $59.00 | $5.90/mg |
| Bio Pepz | 10MG | $60.00 | $6.00/mg |
| PureRx Peptides | 10mg | $65.00 | $6.50/mg |
| Legendary Peptides | 10mg | $87.00 | $8.70/mg |
| Ameano Peptides | 10mg | $88.00 | $8.80/mg |
| Red Fox Peptides | 5 mg | $45.00 | $9.00/mg |
| Onyx Research | 10mg | $95.00 | $9.50/mg |
| Athena Peptides | 10MG | $95.00 | $9.50/mg |
| Sigma Peptides | 10MG | $99.99 | $10.00/mg |
| Triantex | 10mg | $99.99 | $10.00/mg |
| Choice Peps | 5mg | $50.00 | $10.00/mg |
| Growth Guys | 10mg | $100 | $10.00/mg |
| Great Northern Peptides | 10mg | $100 | $10.00/mg |
| Bioscience Peptides | 10MG | $115 | $11.50/mg |
| Purus Peptides | 5MG | $60.00 | $12.00/mg |
| Colorado Research Peptides | 5mg | $60.00 | $12.00/mg |
| NUPEPS Peptides | 10mg | $125 | $12.50/mg |
| VPeptide | 10 mg | $130 | $13.00/mg |
| Prime Lab Peptides | 10mg | $150 | $15.00/mg |
| Peplogix Peptides | 10mg | $150 | $15.00/mg |
| Oasis Peptides | 5mg | $81.00 | $16.20/mg |
| Wholesale Peptide | 5mg | $84.99 | $17.00/mg |
| Buy Peptides Australia | 10mg | $170 | $17.00/mg |
| Loti Labs | 5mg | $89.00 | $17.80/mg |
| Vendor | Best tested purity |
|---|---|
| Optima Chemical Supply, Inc. | 100.0% |
| Oasis Labs | 100.0% |
| Pink Pony Peptides | 100.0% |
| Peptira | 99.8% |
| Kensingtonlabs.co | 99.8% |
| Zztai Peptide | 99.8% |
| HAPPYPEPTIDES.COM | 99.7% |
| MOB Peptides | 99.7% |
| Peptide Crafters | 99.7% |
| wslabus | 99.7% |
| Reta-Peptide | 99.7% |
| Peptide Gurus | 99.6% |
| Tydes Research | 99.5% |
| Qingdao Sigma Chemical QSC | 99.3% |
| Eros Peptides | 99.2% |
| Lipo-Peptide | 99.1% |
Related peptides: Pramlintide.
Independent lab tests: Cagrilintide purity test results.
CagriSema is a fixed-dose combination of cagrilintide 2.4 mg (amylin analog) and semaglutide 2.4 mg (GLP-1 agonist) administered as a single once-weekly injection. It targets two complementary appetite pathways, producing greater weight loss than either component alone. Novo Nordisk filed for FDA approval in 2026.
CagriSema (amylin + GLP-1) and tirzepatide (GIP + GLP-1) target different complementary pathways to GLP-1. CagriSema achieved ~20.4% weight loss at 68 weeks. Tirzepatide achieved ~22.5% at 72 weeks (SURMOUNT-1). Head-to-head data is not yet available. The two represent competing next-generation obesity therapeutics.
Cagrilintide is a long-acting amylin analog researched for weight management. It works differently from GLP-1 agonists and is often studied in combination with other peptides.
CAGRILINTIDE has been studied for: Appetite regulation, Weight management research, Glycemic control. Amylin analog; often researched in combination protocols.
Amylin receptor agonist that may influence satiety signaling, slow gastric emptying, and reduce glucagon secretion.
Vendors with independent lab tests for it: Reta-Peptide, Pink Pony Peptides, Peptide Crafters, Happy Peptides, MOB Peptides.
Vendors stocking it: Direct Peptides UK, VPeptide, OP Labs, Mod Peptide, NUPEPS Peptides, Loti Labs, Bio Pepz, Oasis Peptides, Zztai Peptide, Nexaph, ZePeptide, Pura Peptides, Wolverine Peptides, All Peptides USA, DH Peps, Sigma Peptides, Grey Axis Research, Biomax Research, Ameano Peptides, MODPeptides, Prime Lab Peptides, Prospera Peptides, Onyx Research, Compound Sciences, Triantex, Choice Peps, Wholesale Peptide, Compound Purity, Purus Peptides, Peplogix Peptides, Colorado Research Peptides, Legendary Peptides, Treasure Coast Peptides, Bioscience Peptides, PureGenix Peptides, Anglo Peptides, Ds Peptides, Astra Peptides, Athena Peptides.
Coverage on this site: Oral Wegovy Outruns Foundayo in the First Full Quarter of Oral Competition, Novo names AWS strategic AI partner as CagriSema decision nears, GLP-1 multi-target therapies and manufacturing near 2025 milestones, Obesity Drugs Present Diverse Benefits, Harms, and Discontinuation Rates, The Emerging Role of Amylin: Dr. Garvey on CagriSema and the Future of Obesity Care, Cagrilintide-Semaglutide May Aid Type 2 Diabetes Glycemic Control.
Independent lab results for Cagrilintide: Cagrilintide — Independent Lab Test Results, Cagrilintide 10mg — Independent Lab Test Results.