A peptide hormone produced primarily in the stomach that stimulates appetite, growth hormone release, and fat storage. Known as the "hunger hormone." Growth hormone secretagogues like GHRP-6 and MK-677 act on the ghrelin receptor (GHS-R1a).
"Ghrelin" is filed under Pharmacology in the PeptideAtlas glossary, alongside 29 other terms in that group.
The term applies directly to 10 compound profiles here: Ipamorelin (evidence D), GHRP-6 (evidence D), GHRP-2 (evidence C), MK-677 (evidence C), Hexarelin (evidence C), Alexamorelin (evidence D), Tabimorelin (evidence C), Macimorelin (evidence A), and others. Each profile states the strength of the human evidence rather than only what the compound is claimed to do.
2 other glossary entries refer to this term in their own definition, which is usually the fastest way to see how it is used in practice.
A class of synthetic peptides that stimulate growth hormone release by activating the ghrelin receptor (GHS-R1a). Includes GHRP-2, GHRP-6, hexarelin, and ipamorelin. Each variant has different potency and side-effect profiles regarding hunger, cortisol, and prolactin.
The ghrelin receptor, a G protein-coupled receptor primarily expressed in the pituitary and hypothalamus. Activation by ghrelin or synthetic GHRPs stimulates growth hormone release, appetite, and reward signaling. Also known as the ghrelin receptor.
The proportion of a substance that enters the circulation when introduced into the body and is able to have an active effect. Different administration routes affect bioavailability.
The time required for the concentration of a substance in the body to decrease by half. Determines dosing frequency and accumulation patterns.
Compounds where this applies: Ipamorelin, GHRP-6, GHRP-2, MK-677, Hexarelin, Alexamorelin, Tabimorelin, Macimorelin, Anamorelin, Ghrelin.
Terms that reference this one: GHRP (Growth Hormone Releasing Peptide), GHS-R1a (Growth Hormone Secretagogue Receptor).
More Pharmacology terms: Bioavailability, Half-Life, Pharmacokinetics, Pharmacodynamics, First-Pass Metabolism, Receptor Agonist, Receptor Antagonist, Desensitization, Tachyphylaxis, Downregulation, GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), Glucagon, Amylin, Growth Hormone Secretagogue (GHS), GHRP (Growth Hormone Releasing Peptide), GHRH (Growth Hormone Releasing Hormone), GHS-R1a (Growth Hormone Secretagogue Receptor), Secretagogue, Melanocortin Receptor.