An incretin hormone that stimulates insulin secretion, inhibits glucagon release, slows gastric emptying, and reduces appetite. GLP-1 receptor agonists like semaglutide mimic this hormone.
"GLP-1 (Glucagon-Like Peptide-1)" is filed under Pharmacology in the PeptideAtlas glossary, alongside 29 other terms in that group.
The term applies directly to 1 compound profile here: Tirzepatide (evidence A). Each profile states the strength of the human evidence rather than only what the compound is claimed to do.
The proportion of a substance that enters the circulation when introduced into the body and is able to have an active effect. Different administration routes affect bioavailability.
The time required for the concentration of a substance in the body to decrease by half. Determines dosing frequency and accumulation patterns.
The study of how a drug moves through the body — absorption, distribution, metabolism, and excretion (ADME).
Compounds where this applies: Tirzepatide.
More Pharmacology terms: Bioavailability, Half-Life, Pharmacokinetics, Pharmacodynamics, First-Pass Metabolism, Receptor Agonist, Receptor Antagonist, Desensitization, Tachyphylaxis, Downregulation, GIP (Glucose-Dependent Insulinotropic Polypeptide), Glucagon, Amylin, Ghrelin, Growth Hormone Secretagogue (GHS), GHRP (Growth Hormone Releasing Peptide), GHRH (Growth Hormone Releasing Hormone), GHS-R1a (Growth Hormone Secretagogue Receptor), Secretagogue, Melanocortin Receptor.