A substance that binds to a receptor and activates it, mimicking the action of a naturally occurring substance. Many therapeutic peptides are receptor agonists.
"Receptor Agonist" is filed under Pharmacology in the PeptideAtlas glossary, alongside 29 other terms in that group.
The term applies directly to 3 compound profiles here: Dulaglutide (evidence A), Dermorphin (evidence D), Eloralintide (evidence C). Each profile states the strength of the human evidence rather than only what the compound is claimed to do.
3 other glossary entries refer to this term in their own definition, which is usually the fastest way to see how it is used in practice.
An incretin hormone that stimulates insulin secretion, inhibits glucagon release, slows gastric emptying, and reduces appetite. GLP-1 receptor agonists like semaglutide mimic this hormone.
Delayed gastric emptying causing nausea, vomiting, and early satiety. A recognized side effect of GLP-1 receptor agonists due to their mechanism of slowing gastric motility.
Inflammation of the pancreas causing severe abdominal pain. Monitored as a potential adverse event with GLP-1 receptor agonists. Patients are advised to seek immediate medical attention for severe abdominal pain.
The proportion of a substance that enters the circulation when introduced into the body and is able to have an active effect. Different administration routes affect bioavailability.
Compounds where this applies: Dulaglutide, Dermorphin, Eloralintide.
Terms that reference this one: GLP-1 (Glucagon-Like Peptide-1), Gastroparesis, Pancreatitis.
More Pharmacology terms: Bioavailability, Half-Life, Pharmacokinetics, Pharmacodynamics, First-Pass Metabolism, Receptor Antagonist, Desensitization, Tachyphylaxis, Downregulation, GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), Glucagon, Amylin, Ghrelin, Growth Hormone Secretagogue (GHS), GHRP (Growth Hormone Releasing Peptide), GHRH (Growth Hormone Releasing Hormone), GHS-R1a (Growth Hormone Secretagogue Receptor), Secretagogue, Melanocortin Receptor.