A substance that stimulates the secretion of another substance. In peptide contexts, usually refers to growth hormone secretagogues (GHS) that stimulate pituitary GH release.
"Secretagogue" is filed under Pharmacology in the PeptideAtlas glossary, alongside 29 other terms in that group.
The term applies directly to 13 compound profiles here: Ipamorelin (evidence D), CJC-1295 (evidence D), Sermorelin (evidence C), Tesamorelin (evidence A), GHRP-6 (evidence D), GHRP-2 (evidence C), MK-677 (evidence C), Hexarelin (evidence C), and others. Each profile states the strength of the human evidence rather than only what the compound is claimed to do.
3 other glossary entries refer to this term in their own definition, which is usually the fastest way to see how it is used in practice.
An initial higher dose of a peptide given to rapidly reach therapeutic concentration in the body. Often followed by a lower maintenance dose. Common in protocols for BPC-157 blends and growth hormone secretagogues.
A peptide hormone produced primarily in the stomach that stimulates appetite, growth hormone release, and fat storage. Known as the "hunger hormone." Growth hormone secretagogues like GHRP-6 and MK-677 act on the ghrelin receptor (GHS-R1a).
A measurable biological indicator used to assess normal processes, disease states, or responses to treatment. IGF-1 levels are a common biomarker for growth hormone secretagogue therapy.
The proportion of a substance that enters the circulation when introduced into the body and is able to have an active effect. Different administration routes affect bioavailability.
Compounds where this applies: Ipamorelin, CJC-1295, Sermorelin, Tesamorelin, GHRP-6, GHRP-2, MK-677, Hexarelin, Alexamorelin, Tabimorelin, Macimorelin, Anamorelin, Ghrelin.
Terms that reference this one: Loading Dose, Ghrelin, Biomarker.
More Pharmacology terms: Bioavailability, Half-Life, Pharmacokinetics, Pharmacodynamics, First-Pass Metabolism, Receptor Agonist, Receptor Antagonist, Desensitization, Tachyphylaxis, Downregulation, GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), Glucagon, Amylin, Ghrelin, Growth Hormone Secretagogue (GHS), GHRP (Growth Hormone Releasing Peptide), GHRH (Growth Hormone Releasing Hormone), GHS-R1a (Growth Hormone Secretagogue Receptor), Melanocortin Receptor.