Tesamorelin (tesamorelin acetate) is a synthetic 44-amino-acid analog of human growth hormone-releasing hormone (GHRH) and the only FDA-approved medication for reducing excess abdominal fat in HIV-infected adults with lipodystrophy, marketed as Egrifta. It stimulates endogenous GH and IGF-1 production. Egrifta WR, a new weekly-reconstitution formulation, was FDA-approved in March 2025. Phase 3 trials demonstrated significant visceral fat reduction with a generally well-tolerated safety profile over 26 weeks of therapy.
30 vendors tracked by PeptideAtlas list Tesamorelin, priced from $24.64 to $220. The lowest price per milligram is $4.25/mg at LA Peptides (20MG). 39 independent Janoshik purity tests cover Tesamorelin across 24 vendors. Results range from 97.5% to 99.8%.
Category: Growth Hormone Secretagogue. Evidence rating: A (strong human clinical data).
Clinical status: FDA-approved (Egrifta SV 2019, Egrifta WR March 2025) for HIV-associated lipodystrophy
Tesamorelin binds to and stimulates human GRF (growth hormone-releasing factor) receptors on the anterior pituitary with similar potency as endogenous GRF, stimulating synthesis and release of endogenous growth hormone. This increases IGF-1 and IGFBP-3 levels, leading to increased lipolysis and…
Research base: 9 registered clinical trials and 24 indexed publications reference Tesamorelin.
Safety considerations: Common: injection site reactions (17%), arthralgia (13%), myalgia (6%), peripheral edema (6%); Headache, nausea, and flu-like symptoms reported; May increase blood glucose -- monitoring recommended in diabetics.
Reviewed by the PeptideAtlas Editorial Team.
| Amino-acid sequence | Trans-3-hexenoic acid-GHRH(1-44)-NH2 (44-amino acid modified GHRH) |
|---|---|
| Molecular weight | ~5135.9 g/mol |
| CAS number | 901758-09-6 |
| Half-life | ~26–38 minutes |
| Production method | synthetic |
| Anti-doping status | Prohibited in sport (WADA) |
| US regulatory status | FDA-approved: Egrifta SV (Oct 2019) and Egrifta WR (March 2025) for HIV-associated lipodystrophy. Prescription only. |
| Vendor | Size | Price | Price per mg |
|---|---|---|---|
| LA Peptides | 20MG | $85.00 | $4.25/mg |
| All Peptides USA | 10MG | $49.00 | $4.90/mg |
| Legendary Peptides | 10mg | $49.50 | $4.95/mg |
| Supopeptide | 20mg | $110 | $5.50/mg |
| Choice Peps | 10mg | $59.00 | $5.90/mg |
| Athena Peptides | 10MG | $59.99 | $6.00/mg |
| Evolve BioPep | 10mg | $60.00 | $6.00/mg |
| PureRx Peptides | 10mg | $61.00 | $6.10/mg |
| Panda Peptides | 10mg | $64.99 | $6.50/mg |
| Buy Peptides Australia | 10mg | $65.00 | $6.50/mg |
| protopeptide.is | 10mg | $65.00 | $6.50/mg |
| Sigma Peptides | 10MG | $69.99 | $7.00/mg |
| Purus Peptides | 10MG | $70.00 | $7.00/mg |
| Growth Guys | 20mg | $150 | $7.50/mg |
| BioTech Peptides | 5mg | $38.00 | $7.60/mg |
| Onyx Research | 10mg | $77.00 | $7.70/mg |
| Wholesale Peptide | 10mg | $80.74 | $8.07/mg |
| Compound Purity | 10mg | $83.00 | $8.30/mg |
| AminoVault | 10mg | $84.58 | $8.46/mg |
| Elite Edge Biotech | 10mg | $84.99 | $8.50/mg |
| Prime Lab Peptides | 10mg | $85.00 | $8.50/mg |
| The Peptide Labs | 10MG | $85.00 | $8.50/mg |
| Bioscience Peptides | 10mg | $85.99 | $8.60/mg |
| Premium Peps | 20mg | $220 | $11.00/mg |
| Atomix Research | 5 mg | $59.95 | $11.99/mg |
| Vendor | Best tested purity |
|---|---|
| Modern Peptides | 99.8% |
| Peptide Crafters | 99.8% |
| Peptide Gurus | 99.7% |
| Cocer Peptides | 99.7% |
| liuquanqun | 99.6% |
| Reta-Peptide | 99.6% |
| cellpept | 99.6% |
| Imperial Peptides | 99.6% |
| Zztai Peptide | 99.5% |
| Rayshine Peptide Biochemicals | 99.4% |
| Eros Peptides | 99.4% |
| Homopeptide | 99.4% |
| Hangzhou Mandy Biotechnology | 99.3% |
| XL Peptides | 99.3% |
| Panda Peptides | 99.2% |
| Peptira | 99.2% |
| Mei Peptide | 99.1% |
| HAPPYPEPTIDES.COM | 99.1% |
| Heman Peptide HM | 99.0% |
| Kensingtonlabs.co | 99.0% |
| Amino Alchemy | 99.0% |
| Qingdao Sigma Chemical QSC | 97.5% |
Related peptides: Ipamorelin, CJC-1295, Sermorelin.
Compare: Tesamorelin vs Sermorelin.
Independent lab tests: Tesamorelin purity test results.
No. Per FDA labeling, tesamorelin is not a weight-loss medication and should not be used to treat obesity. It is approved only for reducing excess abdominal fat in HIV-infected adults with lipodystrophy.
Egrifta SV requires daily reconstitution. Egrifta WR (approved March 2025) requires less than half the administration volume and only weekly reconstitution. They have different recommended dosages and are not substitutable.
Fat reduction begins in weeks 1-2, with significant changes at 4-6 weeks and full benefits at 8-12 weeks. Phase 3 trials demonstrated efficacy over 26 weeks of therapy.
Some practitioners use tesamorelin off-label for its GH-stimulating effects on body composition and skin quality (GH and IGF-1 are important in collagen synthesis). However, it is only FDA-approved for HIV-associated lipodystrophy.
Yes, it may increase blood glucose levels. Monitoring is recommended, especially in patients with diabetes or pre-diabetes. Hyperglycemia frequency was similar between treatment and control groups in clinical trials.
Vendors with independent lab tests for it: Reta-Peptide, Eros Peptides, HPR, Happy Peptides.
Vendors stocking it: Direct Peptides UK, BioTech Peptides, SwissChems, LA Peptides, LimitlessBioChem, Mod Peptide, Panda Peptides, Eternal Peptides, Loti Labs, Amino Lair, Zztai Peptide, Evolve BioPep, Nexaph, Wolverine Peptides, All Peptides USA, Sigma Peptides, Biomax Research, NovaPeptide, Ultima Pharmaceuticals, Mei Peptide, MODPeptides, Prime Lab Peptides, Pacific Peptide, Axon Chems, Onyx Research, Compound Sciences, Choice Peps, Wholesale Peptide, Compound Purity, Purus Peptides, Peplogix Peptides, Blue Line Research, Legendary Peptides, Lab Trust Peptides, Supopeptide, Charleston Peptide Supply, Treasure Coast Peptides, Bioscience Peptides, BioPure Peptides.
Coverage on this site: Huberman and Ferriss put peptide science in the mainstream, Turning Back the Clock: Why St. Johns County Patients Are Choosing Physician-Led Peptide Therapy, Unconventional FDA Panel Weighs Future of Banned Peptides, Peptide Stacking Insights From a Functional Medicine Physician, Peptides Explained: BPC-157, Tesamorelin, and Tanning Peptides, Ipamorelin: Selective GH Secretagogue Research in Canada.
Independent lab results for Tesamorelin: Tesamorelin 10mg — Independent Lab Test Results, Tesamorelin — Independent Lab Test Results.