Semaglutide is an FDA-approved GLP-1 receptor agonist (MW ~4113.6 g/mol, molecular formula C187H291N45O59) with 94% sequence homology to human GLP-1. It is approved for type 2 diabetes (Ozempic), chronic weight management (Wegovy), and non-cirrhotic MASH (Wegovy). Developed by Novo Nordisk and first FDA-approved December 5, 2017, it is backed by the extensive STEP and SUSTAIN trial programs involving thousands of patients. There is no generic semaglutide available, and the FDA has warned about counterfeit products.
15 vendors tracked by PeptideAtlas list Semaglutide, priced from $34.00 to $180. The lowest price per milligram is $5.00/mg at Colorado Research Peptides (10mg). 40 independent Janoshik purity tests cover Semaglutide across 22 vendors. Results range from 98.3% to 100.0%.
Category: Metabolic / GLP-1 Agonist. Evidence rating: A (strong human clinical data).
Clinical status: FDA-approved (Ozempic for T2D, Wegovy for obesity)
Semaglutide mimics the GLP-1 hormone by binding to GLP-1 receptors on pancreatic beta cells (glucose-dependent), brain (hypothalamus appetite centers), stomach, and intestines. It stimulates insulin secretion, suppresses glucagon release, slows gastric emptying promoting prolonged fullness, and…
Research base: 704 registered clinical trials and 255 indexed publications reference Semaglutide.
Safety considerations: Common (5%+ in trials): nausea, vomiting, diarrhea, abdominal pain, constipation (usually dose-dependent and transient); Additional common effects: upset stomach, heartburn, burping, gas, bloating, loss of appetite, headache, dizziness, tiredness; Serious but rare: pancreatitis, gallbladder disease, severe allergic reactions (hives, swelling, difficulty breathing).
Reviewed by the PeptideAtlas Editorial Team.
| Molecular formula | C187H291N45O59 |
|---|---|
| Molecular weight | ~4113.6 g/mol |
| Half-life | ~160–168 hours (~7 days) |
| Bioavailability | ~89% SC; lower oral bioavailability (requires empty stomach) |
| Production method | recombinant |
| Anti-doping status | not-prohibited |
| US regulatory status | FDA-approved (Ozempic, Wegovy, Rybelsus). Additional approvals: MASH with fibrosis (Aug 2025), oral 25 mg for weight management (late 2025). 135+ warning letters issued to GLP-1 compounders; proposed permanent ban on 503B GLP-1 compounding. |
| Vendor | Size | Price | Price per mg |
|---|---|---|---|
| Colorado Research Peptides | 10mg | $50.00 | $5.00/mg |
| VPeptide | 10mg | $69.99 | $7.00/mg |
| The Peptide Labs | 10MG | $70.00 | $7.00/mg |
| Great Northern Peptides | 20mg | $150 | $7.50/mg |
| Growth Guys | 10mg | $80.00 | $8.00/mg |
| Buy Peptides Australia | 5mg | $50.00 | $10.00/mg |
| Verasynlabs | 5MG | $54.99 | $11.00/mg |
| Lucky Link Peptides | 10MG | $115 | $11.50/mg |
| Sigma Peptides | 10MG | $125 | $12.50/mg |
| Disguised Research Peptides | 10MG | $140 | $14.00/mg |
| Pharmaqo | 5mg | $84.00 | $16.80/mg |
| Lab Trust Peptides | 10mg | $180 | $18.00/mg |
| AstropeptidesUSA | 5 mg | $150 | $30.00/mg |
| Huaian Hanyou Peptide | 5mg | $150 | $30.00/mg |
| Guangzhou Jeep Biotechnology JEEP | 5mg | $150 | $30.00/mg |
| Vendor | Best tested purity |
|---|---|
| SEMA.BIO | 100.0% |
| Peptide Crafters | 100.0% |
| Polaris Peptides | 99.9% |
| PACIFIC WAVE PEPTIDES | 99.9% |
| usroids.com | 99.8% |
| Qing Li Peptide | 99.8% |
| Pacific Wave | 99.8% |
| AstropeptidesUSA | 99.8% |
| ZLZ Peptide | 99.7% |
| MOB Peptides | 99.7% |
| Panda Peptides | 99.7% |
| Modern Peptides | 99.7% |
| Qingdao Sigma Chemical QSC | 99.7% |
| Reta-Peptide | 99.6% |
| DutchLabs | 99.6% |
| aminopure.peptides | 99.6% |
| [email protected] | 99.4% |
| wslabus | 99.4% |
| Rayshine Peptide Biochemicals | 99.3% |
| Eros Peptides | 99.1% |
Related peptides: Liraglutide, Exenatide, Dulaglutide.
Compare: Semaglutide vs Liraglutide.
Independent lab tests: Semaglutide purity test results.
Compounded semaglutide is not FDA-approved and may not have the same safety, purity, or efficacy as brand-name products. The FDA has issued warnings about certain compounded versions and counterfeit semaglutide products. Compounding pharmacies must comply with 503A/503B regulations.
Semaglutide is a prescription medication. Obtaining it without a valid prescription is illegal in most jurisdictions and potentially dangerous. There is no generic semaglutide available.
Yes. STEP 4 (PMID: 33755728) showed patients switching from semaglutide to placebo regained an average of +6.9% body weight over 48 weeks, while those continuing lost an additional -7.9%. Long-term use or substantial lifestyle changes are needed to maintain results.
All contain semaglutide by Novo Nordisk. Ozempic (injection/tablet) is for T2D, cardiovascular risk reduction, and CKD risk reduction. Wegovy (injection/tablet) is for weight management, cardiovascular risk, and non-cirrhotic MASH. Rybelsus (tablet only) is for T2D. Maximum doses differ: Ozempic up to 2 mg, Wegovy up to 2.4 mg weekly.
Injections are self-administered once weekly subcutaneously. Ozempic starts at 0.25 mg, titrating to 0.5, 1, or 2 mg. Wegovy starts at 0.25 mg, titrating to 2.4 mg. Rybelsus tablets are taken daily (3, 7, or 14 mg). Dose escalation no more than every 4 weeks to minimize GI side effects. Rotate injection sites (abdomen, thighs, upper arms).
Vendors with independent lab tests for it: Polaris Peptides, Reta-Peptide, SEMA.BIO, Qingdao Sigma Chemical QSC.
Vendors stocking it: VPeptide, Mod Peptide, TMates, Hangzhou Mandy Biotechnology, Zztai Peptide, ZePeptide, Wuhan Wansheng Biotechnology, Homopeptide, Sigma Peptides, MODPeptides, Pacific Peptide, Colorado Research Peptides, Lab Trust Peptides, Supopeptide, Verasynlabs, Peptibion, US Chem Labs, Catalyst Peptides, Grewo Peptide, Hangzhou Qihang Xingcheng, Buy Peptides Australia, uwa-biotech, AstropeptidesUSA, utherpeptide, Uther, Disguised Alpha, Growth Guys, Great Northern Peptides, The Peptide Labs, Toronto Peptides, Montreal Peptides, Advanced Peptides Australia, Huaian Hanyou Peptide, Guangzhou Jeep Biotechnology JEEP, Shandong Shengyuan Peptide Technology, Hunan GoodPeptides Biotech Co, Xianhong Tong XHT Peptides, Shenzhen Loga Tech LG LOGA, ZZQ Peptides.
Coverage on this site: GLP-1 Use Reaches 18% Of U.S. Adults As Chains Rework Menus, Quebec Court Bars Canlab Research From Selling Unauthorized Peptides, Employers Drop GLP-1 Weight-Loss Coverage as Costs Climb and Use Rises, Best Canadian Peptide Vendors 2026: Ranked by Published Evidence, Semaglutide hsCRP cut of 37.8% in SELECT suggests anti-inflammatory role, Seventh Victorian Case Links Counterfeit Retatrutide to Liver Toxicity.
Independent lab results for Semaglutide: Semaglutide 10mg — Independent Lab Test Results, Semaglutide — Independent Lab Test Results, Semaglutide 5 Mg — Independent Lab Test Results.