Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro, MW ~751.89 g/mol) developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is a structural analogue of the immunomodulatory peptide tuftsin with an added Pro-Gly-Pro sequence for stability. Approved in Russia as an anxiolytic and nootropic nasal spray, it crosses the blood-brain barrier to enhance GABAergic neurotransmission, modulate monoamine systems, and regulate neuropeptide Y signaling. A 2008 study of 62 patients with GAD showed Selank comparable to medazepam for anxiety reduction but with no sedation, cognitive impairment, or dependence risk. Half-life is approximately 2-10 minutes.
34 vendors tracked by PeptideAtlas list Selank, priced from $24.99 to $175. The lowest price per milligram is $2.50/mg at Prospera Peptides (10mg). 18 independent Janoshik purity tests cover Selank across 15 vendors. Results range from 98.0% to 100.0%.
Category: Nootropic / Anxiolytic. Evidence rating: D (animal/preclinical only).
Clinical status: Approved in Russia as an anxiolytic nasal spray; not approved elsewhere
Selank (C33H57N11O9, half-life ~2-10 minutes) crosses the blood-brain barrier. It acts as a positive allosteric modulator of GABA-A receptors, increasing GABA binding affinity without directly activating the receptor (similar to benzodiazepines but without sedation or dependence). It enhances…
Research base: 1 registered clinical trial and 18 indexed publications reference Selank.
Safety considerations: Safety is excellent with minimal adverse effects in published studies; A peer-reviewed study stated Selank had desirable effects of low-dose benzodiazepines with none of the side effects; No dependence potential, no withdrawal effects -- unlike benzodiazepines.
Reviewed by the PeptideAtlas Editorial Team.
| Amino-acid sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro (tuftsin analog with Pro-Gly-Pro extension) |
|---|---|
| Molecular weight | ~751.9 g/mol |
| CAS number | 129954-34-3 |
| Half-life | ~3–5 minutes (parent compound); active metabolites persist longer |
| Production method | synthetic |
| Anti-doping status | not-listed |
| US regulatory status | Not FDA-approved. Research chemical only. |
| Vendor | Size | Price | Price per mg |
|---|---|---|---|
| Prospera Peptides | 10mg | $25.00 | $2.50/mg |
| Domestic Peps | 10mg | $25.00 | $2.50/mg |
| Archer Peptides | 10MG | $28.00 | $2.80/mg |
| PureRx Peptides | 10mg | $28.00 | $2.80/mg |
| Petratide Science | 10mg | $29.95 | $3.00/mg |
| Orbitrex Peptides | 30mg | $89.99 | $3.00/mg |
| Particle Peptides | 10mg | $30.75 | $3.08/mg |
| Kitsune Compounds | 10mg | $32.99 | $3.30/mg |
| Wholesale Peptide | 10mg | $33.99 | $3.40/mg |
| Evolve BioPep | 10mg | $35.00 | $3.50/mg |
| Legendary Peptides | 10mg | $36.00 | $3.60/mg |
| Mammoth Muscle Peptides | 10mg | $38.00 | $3.80/mg |
| All Peptides USA | 10 MG | $39.00 | $3.90/mg |
| Choice Peps | 10mg | $39.00 | $3.90/mg |
| Purus Peptides | 10MG | $39.00 | $3.90/mg |
| NUPEPS Peptides | 10mg | $43.00 | $4.30/mg |
| Athena Peptides | 10MG | $48.00 | $4.80/mg |
| Verasynlabs | 5MG | $24.99 | $5.00/mg |
| Pulse Research Expansion | 10MG | $49.99 | $5.00/mg |
| Compound Purity | 10mg | $50.00 | $5.00/mg |
| Peak Peptides | 10mg | $50.00 | $5.00/mg |
| Growth Guys | 10mg | $50.00 | $5.00/mg |
| Red Fox Peptides | 20 mg | $100 | $5.00/mg |
| Pacific Peptide | 10mg | $55.00 | $5.50/mg |
| AstropeptidesUSA | 10 mg | $55.00 | $5.50/mg |
| Vendor | Best tested purity |
|---|---|
| Peptide Crafters | 100.0% |
| Pink Pony Peptides | 99.9% |
| Peptide Gurus | 99.9% |
| Growth Guys Canada | 99.9% |
| Peptira | 99.8% |
| Panda Peptides LLC | 99.8% |
| Henan Sahe Peptide | 99.8% |
| Certified Peptides | 99.8% |
| Imperial Peptides | 99.7% |
| aurapp.5188 | 99.7% |
| HPR | 99.6% |
| wslabus | 99.6% |
| ZLZ Peptide | 99.4% |
| Kensingtonlabs.co | 99.3% |
| Qingdao Sigma Chemical QSC | 98.0% |
Related peptides: N-Acetyl Selank Amidate.
Independent lab tests: Selank purity test results.
Selank enhances GABA-A receptor activity as a positive allosteric modulator (similar mechanism to benzodiazepines), but crucially without sedation, cognitive impairment, dependence, or withdrawal effects. Users feel relaxed while maintaining mental clarity.
Yes, approved in Russia and some CIS states for GAD as an anxiolytic and nootropic nasal spray. Not approved in any Western country.
Research protocols use 250-500 mcg intranasally once or twice daily. Selank has poor oral bioavailability but is effective intranasally (bypasses first-pass metabolism) or subcutaneously. Acute anxiety effects within hours; chronic stress resilience improves over 2-4 weeks.
No convincing evidence that cycling is required, but the precautionary recommendation is a week-long break after every 1-2 weeks of administration, as long-term continuous use is understudied.
Both are Russian-developed heptapeptides with Pro-Gly-Pro stabilization. Selank is derived from tuftsin (anxiolytic, GABAergic, immune-modulating). Semax is derived from ACTH 4-10 (neuroprotective, BDNF-enhancing, cognitive). They target different systems and are sometimes used in combination.
Vendors with independent lab tests for it: Growth Guys Canada, Pink Pony Peptides, HPR, Peptide Crafters.
Vendors stocking it: Direct Peptides UK, LA Peptides, Polar Peptides, Risynth Bio, NUPEPS Peptides, Amino Lair, Zztai Peptide, Evolve BioPep, Nexaph, All Peptides USA, DH Peps, Biomax Research, Ultima Pharmaceuticals, Pulse Research Expansion, Prime Lab Peptides, Pacific Peptide, Mammoth Muscle Peptides, Axon Chems, Lab Rat Peptide, Prospera Peptides, Onyx Research, Choice Peps, Wholesale Peptide, BleauGenics, Compound Purity, Purus Peptides, Peplogix Peptides, Petratide Science, Modern Peptides, Blue Line Research, SupraChems, Legendary Peptides, Amino Club, Charleston Peptide Supply, Treasure Coast Peptides, Verasynlabs, BioPure Peptides, Amino Nova, US Chem Labs, Kitsune Compounds.
Coverage on this site: Selank Peptide Research: Anxiety, Cognition, and Neuroimmune Studies, DSIP Peptide: Sleep Signaling and Circadian Rhythm Research in Canada, Boost Focus and Clarity with Selank and Semax Duo, Oxytocin's Vital Role in Social and Relationship Bonds, Semax: Guide to the ACTH-Derived Nootropic Peptide, High-Purity Research Peptides for Lab Use.
Independent lab results for Selank: Selank 10mg — Independent Lab Test Results, Selank 5mg — Independent Lab Test Results, Selank — Independent Lab Test Results.