PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and non-selective melanocortin receptor agonist (MC3R/MC4R) derived as an active metabolite of Melanotan II. It is FDA-approved (2019) for hypoactive sexual desire disorder (HSDD) in premenopausal women, marketed as Vyleesi. Unlike PDE5 inhibitors that target vascular blood flow, PT-141 acts on the brain's melanocortin system to increase libido and arousal, effective in both men and women through central nervous system pathways.
25 vendors tracked by PeptideAtlas list PT-141, priced from $18.00 to $169. The lowest price per milligram is $1.69/mg at Supopeptide (100mg). 10 independent Janoshik purity tests cover PT-141 across 10 vendors. Results range from 99.3% to 100.0%.
Category: Sexual Health. Evidence rating: A (strong human clinical data).
Clinical status: FDA-approved (Vyleesi for HSDD in premenopausal women)
PT-141 (MW ~1025 g/mol, C50H68N14O10, half-life 2-6 hours) is a synthetic analog of alpha-MSH targeting MC3R and MC4R. MC4R activation in the CNS enhances dopamine release in the nucleus accumbens and medial preoptic area, increasing sexual motivation. Subcutaneous bioavailability is approximately…
Research base: 6 registered clinical trials and 32 indexed publications reference PT-141.
Safety considerations: Common: nausea (~40%, most common and dose-limiting), flushing (50-70%), headache (10-25%), injection site reactions; Transient increases in blood pressure and heart rate; not recommended for uncontrolled hypertension or cardiovascular disease; Skin hyperpigmentation with repeated use (MC1R agonism); darker-skinned patients more susceptible; resolution not confirmed in all patients.
Reviewed by the PeptideAtlas Editorial Team.
| Amino-acid sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
|---|---|
| Molecular weight | ~1025.2 g/mol |
| CAS number | 189691-06-3 |
| Half-life | ~2.5 hours |
| Bioavailability | ~25% SC |
| Production method | synthetic |
| Anti-doping status | not-listed |
| US regulatory status | FDA-approved (Vyleesi, 2019) for HSDD in premenopausal women. 1.75 mg SC on-demand, max 8 doses/month. |
| Vendor | Size | Price | Price per mg |
|---|---|---|---|
| Supopeptide | 100mg | $169 | $1.69/mg |
| PureRx Peptides | 10mg | $18.00 | $1.80/mg |
| Prospera Peptides | 10mg | $20.00 | $2.00/mg |
| Wholesale Peptide | 10mg | $28.04 | $2.80/mg |
| All Peptides USA | 10mg | $29.00 | $2.90/mg |
| Evolve BioPep | 10mg | $30.00 | $3.00/mg |
| Sigma Peptides | 10MG | $34.99 | $3.50/mg |
| Arcane Peptides | 10mg | $35.00 | $3.50/mg |
| Purus Peptides | 10MG | $39.00 | $3.90/mg |
| Atomix Research | 10 mg | $39.99 | $4.00/mg |
| Sentinel Valor | 10MG | $40.00 | $4.00/mg |
| Protide Health | 10mg | $45.00 | $4.50/mg |
| Red Fox Peptides | 10 mg | $45.00 | $4.50/mg |
| The Peptide Labs | 10MG | $45.00 | $4.50/mg |
| Pepix Labs | 10MG | $50.00 | $5.00/mg |
| Compound Purity | 10mg | $50.00 | $5.00/mg |
| Peplogix Peptides | 10mg | $50.00 | $5.00/mg |
| Growth Guys | 10mg | $50.00 | $5.00/mg |
| Great Northern Peptides | 10mg | $55.00 | $5.50/mg |
| Pharma Grade Peptides | 10MG | $55.99 | $5.60/mg |
| Prime Lab Peptides | 10mg | $60.00 | $6.00/mg |
| Bioscience Peptides | 10mg | $62.00 | $6.20/mg |
| Flourish Global Peptide | 10mg | $80.00 | $8.00/mg |
| M-Peptides | 10mg | $120 | $12.00/mg |
| Lipeptides | 10mg | $141 | $14.10/mg |
| Vendor | Best tested purity |
|---|---|
| MOB Peptides | 100.0% |
| Eros Peptides | 99.9% |
| XL Peptides | 99.9% |
| Peptide Gurus | 99.9% |
| Panda Peptides LLC | 99.9% |
| Polaris Peptides | 99.8% |
| Kensingtonlabs.co | 99.8% |
| Qingdao Sigma Chemical QSC | 99.7% |
| HAPPYPEPTIDES.COM | 99.3% |
Related peptides: Bremelanotide.
PT-141 is the research name. Vyleesi is the FDA-approved brand (bremelanotide) for HSDD in premenopausal women at 1.75 mg SC, taken 45 minutes before anticipated activity.
Double-blind placebo-controlled studies showed significant improvements in erectile function with intranasal PT-141 in men with ED. However, it is not FDA-approved for men.
PT-141 works on the brain's melanocortin system to increase desire via dopamine release. Viagra works peripherally on blood flow via PDE5 inhibition. PT-141 targets desire; Viagra targets erectile mechanics.
Yes. Bremelanotide is the active metabolite of Melanotan II, isolated as the compound responsible for sexual arousal effects. It has a more targeted profile than MT-II.
The FDA labeling restricts use to 8 doses/month based on clinical trial protocols and to limit cumulative nausea burden and blood pressure effects.
Vendors with independent lab tests for it: Polaris Peptides, Optima Chemical Supplies Inc, Happy Peptides, MOB Peptides.
Vendors stocking it: Direct Peptides UK, M-Peptides, Amino Lair, Zztai Peptide, Evolve BioPep, Pepix Labs, All Peptides USA, Sigma Peptides, Jiuzhou Peptide, Ultima Pharmaceuticals, Prime Lab Peptides, Prospera Peptides, Wholesale Peptide, Compound Purity, Purus Peptides, Peplogix Peptides, Modern Peptides, Supopeptide, Charleston Peptide Supply, Treasure Coast Peptides, Bioscience Peptides, BioPure Peptides, Archer Peptides, PureRx Peptides, RipTidez, Catalyst Peptides, Sentinel Valor, Protide Health, Tide Labs, Bluewell Peptides, utherpeptide, Uther, Disguised Alpha, Growth Guys, Great Northern Peptides, The Peptide Labs, Toronto Peptides, Arcane Peptides, Montreal Peptides, Pure Peptides UK.
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