A substance that selectively eliminates senescent (aged, non-dividing) cells. FOXO4-DRI is an experimental senolytic peptide studied in cell and animal models.
"Senolytic" is filed under Pharmacology in the PeptideAtlas glossary, alongside 29 other terms in that group.
The term applies directly to 1 compound profile here: FOXO4-DRI (evidence D). Each profile states the strength of the human evidence rather than only what the compound is claimed to do.
3 other glossary entries refer to this term in their own definition, which is usually the fastest way to see how it is used in practice.
Cells that have permanently stopped dividing but resist normal programmed death (apoptosis). They accumulate with age and secrete inflammatory factors (SASP) that damage surrounding tissue. Senolytic peptides like FOXO4-DRI aim to selectively clear these cells.
The cocktail of pro-inflammatory cytokines, chemokines, growth factors, and proteases secreted by senescent cells. SASP contributes to chronic inflammation, tissue dysfunction, and age-related disease. Clearing SASP-producing cells is the goal of senolytic therapies.
Programmed cell death — a controlled process by which damaged or unnecessary cells self-destruct. Senolytic peptides like FOXO4-DRI work by re-enabling apoptosis in senescent cells that have become resistant to it.
The proportion of a substance that enters the circulation when introduced into the body and is able to have an active effect. Different administration routes affect bioavailability.
Compounds where this applies: FOXO4-DRI.
Terms that reference this one: Senescent Cells, SASP (Senescence-Associated Secretory Phenotype), Apoptosis.
More Pharmacology terms: Bioavailability, Half-Life, Pharmacokinetics, Pharmacodynamics, First-Pass Metabolism, Receptor Agonist, Receptor Antagonist, Desensitization, Tachyphylaxis, Downregulation, GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), Glucagon, Amylin, Ghrelin, Growth Hormone Secretagogue (GHS), GHRP (Growth Hormone Releasing Peptide), GHRH (Growth Hormone Releasing Hormone), GHS-R1a (Growth Hormone Secretagogue Receptor), Secretagogue.