Cells that have permanently stopped dividing but resist normal programmed death (apoptosis). They accumulate with age and secrete inflammatory factors (SASP) that damage surrounding tissue. Senolytic peptides like FOXO4-DRI aim to selectively clear these cells.
"Senescent Cells" is filed under Pharmacology in the PeptideAtlas glossary, alongside 29 other terms in that group.
The term applies directly to 2 compound profiles here: FOXO4-DRI (evidence D), FOXO4-DRI (evidence D). Each profile states the strength of the human evidence rather than only what the compound is claimed to do.
2 other glossary entries refer to this term in their own definition, which is usually the fastest way to see how it is used in practice.
The cocktail of pro-inflammatory cytokines, chemokines, growth factors, and proteases secreted by senescent cells. SASP contributes to chronic inflammation, tissue dysfunction, and age-related disease. Clearing SASP-producing cells is the goal of senolytic therapies.
Programmed cell death — a controlled process by which damaged or unnecessary cells self-destruct. Senolytic peptides like FOXO4-DRI work by re-enabling apoptosis in senescent cells that have become resistant to it.
The proportion of a substance that enters the circulation when introduced into the body and is able to have an active effect. Different administration routes affect bioavailability.
The time required for the concentration of a substance in the body to decrease by half. Determines dosing frequency and accumulation patterns.
Compounds where this applies: FOXO4-DRI, FOXO4-DRI.
Terms that reference this one: SASP (Senescence-Associated Secretory Phenotype), Apoptosis.
More Pharmacology terms: Bioavailability, Half-Life, Pharmacokinetics, Pharmacodynamics, First-Pass Metabolism, Receptor Agonist, Receptor Antagonist, Desensitization, Tachyphylaxis, Downregulation, GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), Glucagon, Amylin, Ghrelin, Growth Hormone Secretagogue (GHS), GHRP (Growth Hormone Releasing Peptide), GHRH (Growth Hormone Releasing Hormone), GHS-R1a (Growth Hormone Secretagogue Receptor), Secretagogue.