A proton-coupled peptide transporter (SLC15A1) in the intestinal epithelium that absorbs di- and tripeptides from digested food. It is the primary mechanism by which short oral peptides and bioregulators may achieve systemic absorption. Larger peptides cannot use this transporter.
"PepT1 Transporter" is filed under Pharmacology in the PeptideAtlas glossary, alongside 29 other terms in that group.
The proportion of a substance that enters the circulation when introduced into the body and is able to have an active effect. Different administration routes affect bioavailability.
The time required for the concentration of a substance in the body to decrease by half. Determines dosing frequency and accumulation patterns.
The study of how a drug moves through the body — absorption, distribution, metabolism, and excretion (ADME).
More Pharmacology terms: Bioavailability, Half-Life, Pharmacokinetics, Pharmacodynamics, First-Pass Metabolism, Receptor Agonist, Receptor Antagonist, Desensitization, Tachyphylaxis, Downregulation, GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), Glucagon, Amylin, Ghrelin, Growth Hormone Secretagogue (GHS), GHRP (Growth Hormone Releasing Peptide), GHRH (Growth Hormone Releasing Hormone), GHS-R1a (Growth Hormone Secretagogue Receptor), Secretagogue.