Vialox (Pentapeptide-3) is a competitive antagonist of the postsynaptic muscular nicotinic acetylcholine receptor. It reduces muscle contraction and relaxes expression lines, providing anti-wrinkle effects through topical application.
Category: Cosmetic. Evidence rating: D (animal/preclinical only).
Clinical status: Cosmetic ingredient
Blocks acetylcholine binding at the postsynaptic nAChR on muscle cells, inhibiting contraction and relaxing expression lines. Similar mechanism to SYN-AKE but targeting a different receptor subtype.
Safety considerations: Well-tolerated topically.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
Related peptides: Decapeptide-12, Melanostatin-DM (Nonapeptide-2), Nonapeptide-1.
Both target nicotinic acetylcholine receptors to reduce muscle contraction, but Vialox targets the postsynaptic receptor directly while SYN-AKE mimics snake venom activity. Both are used in anti-wrinkle cosmetics.
Vialox (Pentapeptide-3) is a synthetic cosmetic peptide that competitively inhibits acetylcholine binding at the neuromuscular junction, reducing muscle contraction and associated expression wrinkles.
VIALOX has been studied for: Muscle relaxation, Expression wrinkle reduction, Botox-like effects, Skin smoothing. Cosmetic peptide; nAChR antagonist. Similar mechanism to Syn-Ake but different target site.
Competitively antagonizes the acetylcholine receptor at the post-synaptic membrane, reducing muscle depolarization and contraction at the neuromuscular junction.