Melanostatin-DM (Nonapeptide-2) is a synthetic peptide that acts as an MSH antagonist. It reduces melanin transfer and production for skin brightening and hyperpigmentation treatment in cosmetic formulations.
Category: Cosmetic. Evidence rating: D (animal/preclinical only).
Clinical status: Cosmetic ingredient
Melanostatin-DM antagonizes MSH receptor binding on melanocytes, reducing melanin synthesis signaling. It also inhibits melanosome transfer from melanocytes to keratinocytes, reducing visible pigmentation.
Safety considerations: Well-tolerated in topical application.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
Related peptides: Decapeptide-12, Nonapeptide-1, Pentapeptide-18 (Leuphasyl).
Melanostatin-DM (Nonapeptide-2) is a synthetic peptide that acts as an MSH antagonist. It reduces melanin transfer and production for skin brightening and hyperpigmentation treatment in cosmetic formulations.
On the PeptideAtlas A–F scale, Melanostatin-DM (Nonapeptide-2) is rated D (Preclinical Only). Mostly animal or preclinical evidence
Cosmetic ingredient
Melanostatin-DM antagonizes MSH receptor binding on melanocytes, reducing melanin synthesis signaling. It also inhibits melanosome transfer from melanocytes to keratinocytes, reducing visible pigmentation.
Melanostatin-DM (Nonapeptide-2) is studied in the context of: Cosmetic Skincare. These are research areas, not approved uses.