Decapeptide-12 is a synthetic 10-amino-acid peptide that inhibits melanin production by suppressing tyrosinase activity. It is used in cosmetic formulations for skin brightening and hyperpigmentation treatment, marketed as a safer alternative to hydroquinone.
Category: Cosmetic. Evidence rating: D (animal/preclinical only).
Clinical status: Cosmetic ingredient
Decapeptide-12 inhibits tyrosinase enzyme activity, reducing melanin synthesis in melanocytes. This leads to decreased pigmentation and skin brightening without the cytotoxicity associated with hydroquinone.
Safety considerations: Well-tolerated in topical application; Minimal systemic absorption.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
Related peptides: Melanostatin-DM (Nonapeptide-2), Nonapeptide-1, Pentapeptide-18 (Leuphasyl).
It does not carry the ochronosis or cytotoxicity risks associated with hydroquinone. However, it has far less clinical evidence supporting its efficacy for hyperpigmentation.
Decapeptide-12 is a synthetic skin-lightening peptide that inhibits melanin production by targeting tyrosinase activity, used in cosmetic formulations for hyperpigmentation and dark spot treatment.
DECAPEPTIDE-12 has been studied for: Skin brightening, Hyperpigmentation reduction, Dark spot treatment, Even skin tone. Cosmetic peptide; alternative to hydroquinone for skin lightening.
Inhibits tyrosinase enzyme activity and reduces melanin transfer to keratinocytes, resulting in decreased melanin deposition and lighter skin appearance.