Nonapeptide-1 competes with alpha-MSH at the MC1 receptor on melanocytes, reducing melanin synthesis. It is used in cosmetic skin-lightening products as an alternative to traditional depigmenting agents.
Category: Cosmetic. Evidence rating: D (animal/preclinical only).
Clinical status: Cosmetic ingredient
Competitive antagonism at MC1R blocks alpha-MSH signaling, suppressing cAMP pathway activation in melanocytes and reducing melanin synthesis.
Safety considerations: Well-tolerated topically.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
Related peptides: Decapeptide-12, Melanostatin-DM (Nonapeptide-2), Pentapeptide-18 (Leuphasyl).
Nonapeptide-1 is a synthetic peptide that inhibits melanin synthesis by blocking alpha-MSH binding to MC1R receptors, used in cosmetic formulations for skin brightening.
NONAPEPTIDE-1 has been studied for: Melanin inhibition, Skin brightening, Pigmentation control, UV damage protection. Cosmetic peptide; MC1R antagonist for depigmentation. Also known as Melanostatine.
Antagonizes alpha-MSH at the MC1R receptor on melanocytes, reducing cAMP-mediated activation of tyrosinase and downstream melanin synthesis pathways.
Coverage on this site: Peptide Skincare: Botox-Like Results Without Injections.