SYN-COLL mimics thrombospondin-1 activation of TGF-beta, stimulating collagen synthesis in fibroblasts for anti-wrinkle and skin-firming benefits.
Category: Cosmetic. Evidence rating: D (animal/preclinical only).
Clinical status: Cosmetic ingredient
Mimics thrombospondin-1 signaling to activate TGF-beta pathway, stimulating fibroblast collagen I, III, and IV production without requiring UV-induced damage as a trigger.
Safety considerations: Well-tolerated topically.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
Related peptides: Decapeptide-12, Melanostatin-DM (Nonapeptide-2), Nonapeptide-1.
Syn-Coll (Palmitoyl Tripeptide-5) is a cosmetic peptide that stimulates collagen production by mimicking thrombospondin-1 signaling, reducing wrinkle depth and improving skin elasticity.
SYN-COLL has been studied for: Collagen stimulation, Wrinkle depth reduction, Skin elasticity, TGF-beta activation. Cosmetic peptide; thrombospondin-1 mimetic for collagen induction.
Mimics the active site of thrombospondin-1, activating latent TGF-beta and triggering downstream collagen I and III synthesis in dermal fibroblasts.
Coverage on this site: Peptide Skincare: Botox-Like Results Without Injections, Palmitoyl Tripeptide: Multi-Benefit Peptide for Skin Care.