SYN-AKE is a synthetic tripeptide that mimics waglerin-1 from Temple Viper venom. It acts as a muscular nicotinic acetylcholine receptor antagonist, reducing muscle contraction frequency for wrinkle smoothing.
Category: Cosmetic. Evidence rating: D (animal/preclinical only).
Clinical status: Cosmetic ingredient
Competitive antagonism at the muscular nicotinic acetylcholine receptor (nAChR) reduces muscle contraction frequency, relaxing expression lines and reducing wrinkle depth similar to a mild neurotoxin effect.
Safety considerations: Well-tolerated topically.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
Related peptides: Decapeptide-12, Melanostatin-DM (Nonapeptide-2), Nonapeptide-1.
No. It is a synthetic peptide that mimics the action of waglerin-1, a compound found in Temple Viper venom. No actual venom is used in production.
Syn-Ake is a synthetic tripeptide that mimics the paralytic mechanism of Waglerin-1 from temple viper venom, used in cosmetic formulations to reduce the appearance of wrinkles.
SYN-AKE has been studied for: Wrinkle smoothing, Muscle relaxation, Snake venom-inspired anti-aging, Expression line reduction. Cosmetic peptide; viper venom mimetic. Marketed as 'snake venom cream' ingredient.
Mimics Waglerin-1 peptide to competitively antagonize nicotinic acetylcholine receptors (nAChR) at the neuromuscular junction, reducing muscle cell contraction frequency.