Rigin reduces IL-6 secretion by keratinocytes after UVB exposure, helping reduce chronic low-grade inflammation in aging skin (inflammaging). It is a key component of the Matrixyl 3000 complex alongside Palmitoyl Oligopeptide.
Category: Cosmetic. Evidence rating: D (animal/preclinical only).
Clinical status: Cosmetic ingredient
Inhibits IL-6 secretion from UVB-exposed keratinocytes. Modulates complement system activity and dampens chronic inflammatory signaling associated with skin aging.
Safety considerations: Well-tolerated topically.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
Related peptides: Decapeptide-12, Melanostatin-DM (Nonapeptide-2), Nonapeptide-1.
Rigin (Palmitoyl Tetrapeptide-7) is a lipopeptide that reduces inflammation-driven skin aging by inhibiting IL-6 secretion, commonly paired with Pal-GHK in anti-aging formulations.
RIGIN has been studied for: Anti-inflammatory, Inflammaging reduction, IL-6 suppression, Skin aging prevention. Cosmetic lipopeptide; key ingredient in Matrixyl 3000 alongside Pal-GHK.
Suppresses interleukin-6 (IL-6) and other pro-inflammatory cytokine release from keratinocytes and immune cells, reducing chronic low-grade inflammation (inflammaging) in skin tissue.