Pal-GHK is a lipid-modified version of the GHK tripeptide designed for enhanced skin penetration. The palmitoyl group increases lipophilicity. It is a key component of the Matrixyl 3000 complex and stimulates collagen production.
Category: Cosmetic. Evidence rating: D (animal/preclinical only).
Clinical status: Cosmetic ingredient
The palmitoyl group enhances transdermal delivery through the stratum corneum. Once delivered, the GHK moiety activates collagen synthesis and ECM remodeling via TGF-beta pathway activation.
Safety considerations: Well-tolerated topically.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
Related peptides: Decapeptide-12, Melanostatin-DM (Nonapeptide-2), Nonapeptide-1.
Pal-GHK (Palmitoyl Tripeptide-1) is a lipopeptide form of GHK that enhances skin penetration, used in cosmetic formulations to stimulate collagen production and skin repair.
PAL-GHK has been studied for: Enhanced collagen synthesis, Skin repair, Anti-wrinkle effects, Improved skin penetration. Lipopeptide form of GHK; key ingredient in Matrixyl 3000 alongside Pal-GQPR.
Palmitoylation of the GHK tripeptide sequence improves lipophilicity and dermal penetration. Activates fibroblasts via TGF-beta signaling to produce collagen, glycosaminoglycans, and elastin.
Coverage on this site: Palmitoyl Tripeptide: Multi-Benefit Peptide for Skin Care.