A signaling pathway used by cytokines, interferons, and growth factors to regulate immune responses, cell growth, and differentiation. Some immunomodulatory peptides interact with JAK/STAT signaling to modulate inflammation.
"JAK/STAT Pathway" is filed under Signaling Pathways in the PeptideAtlas glossary, alongside 7 other terms in that group.
A protein complex that controls transcription of inflammatory genes. When activated, NF-κB drives production of pro-inflammatory cytokines. Several peptides (KPV, BPC-157, Thymosin Alpha-1) are studied for their ability to inhibit NF-κB, reducing inflammation.
A central intracellular signaling cascade that regulates cell growth, metabolism, survival, and protein synthesis. Activated by growth factors including IGF-1 and insulin. Many anabolic and growth-promoting peptides exert effects through this pathway. mTOR inhibition (e.g., by rapamycin) is a separate longevity research strategy.
A cellular energy sensor activated when ATP levels are low (e.g., during exercise or fasting). AMPK activation promotes glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and autophagy. AICAR (a nucleoside analog, not a peptide) activates AMPK indirectly via its intracellular metabolite ZMP; the mitochondrial-derived peptide MOTS-c also activates AMPK signaling.
More Signaling Pathways terms: NF-κB (Nuclear Factor Kappa B), PI3K/AKT/mTOR Pathway, AMPK (AMP-Activated Protein Kinase), CREB (cAMP Response Element-Binding Protein), BDNF (Brain-Derived Neurotrophic Factor), SNARE Complex, MAPK/ERK Pathway.