The date after which a compounded preparation should not be used. Determined by the compounding pharmacy based on stability data. Differs from expiration date, which applies to manufactured drugs.
"Beyond-Use Date (BUD)" is filed under Storage & Stability in the PeptideAtlas glossary, alongside 5 other terms in that group.
A cycle of freezing and thawing a substance, which can damage peptide structure through ice crystal formation and aggregation. Multiple freeze-thaw cycles significantly degrade peptides; aliquoting prevents this.
The clumping together of peptide molecules, often caused by heat, agitation, or repeated freeze-thaw cycles. Aggregated peptides may lose potency and can trigger immune reactions if injected.
A common peptide degradation reaction where asparagine or glutamine residues lose an amide group. Accelerated by heat and alkaline pH. Detected on COAs as impurity peaks.
More Storage & Stability terms: Freeze-Thaw Cycle, Aggregation, Deamidation, Oxidation, Desiccant.