The clumping together of peptide molecules, often caused by heat, agitation, or repeated freeze-thaw cycles. Aggregated peptides may lose potency and can trigger immune reactions if injected.
"Aggregation" is filed under Storage & Stability in the PeptideAtlas glossary, alongside 5 other terms in that group.
The term applies directly to 5 compound profiles here: Semax (evidence D), Pramlintide (evidence A), Amylin (evidence B), Vasopressin (evidence A), Eptifibatide (evidence A). Each profile states the strength of the human evidence rather than only what the compound is claimed to do.
1 other glossary entry refer to this term in their own definition, which is usually the fastest way to see how it is used in practice.
A cycle of freezing and thawing a substance, which can damage peptide structure through ice crystal formation and aggregation. Multiple freeze-thaw cycles significantly degrade peptides; aliquoting prevents this.
A common peptide degradation reaction where asparagine or glutamine residues lose an amide group. Accelerated by heat and alkaline pH. Detected on COAs as impurity peaks.
A degradation reaction where methionine, cysteine, or tryptophan residues in peptides react with oxygen. Exposure to light, air, or peroxides accelerates oxidation. Causes loss of potency.
Compounds where this applies: Semax, Pramlintide, Amylin, Vasopressin, Eptifibatide.
Terms that reference this one: Freeze-Thaw Cycle.
More Storage & Stability terms: Freeze-Thaw Cycle, Deamidation, Oxidation, Desiccant, Beyond-Use Date (BUD).