Tripeptide-29 (Gly-Pro-Hyp) is the most abundant repeating tripeptide unit in type I collagen, representing the fundamental building block of the collagen triple helix. As a cosmetic ingredient, it is used as a collagen signal peptide to stimulate fibroblast collagen production. The rationale is that collagen-derived fragments serve as feedback signals for new collagen synthesis. While the role of Gly-Pro-Hyp in collagen biology is well established, clinical evidence for topical application as an anti-aging ingredient is very limited.
Category: Cosmetic Peptide. Evidence rating: F (anecdotal/unsupported).
Clinical status: Cosmetic ingredient. Very limited clinical data for topical use.
Collagen consists of repeating Gly-X-Y triplets, where X is frequently proline and Y is frequently hydroxyproline. Gly-Pro-Hyp is the most common of these triplets. When applied topically or present as a product of collagen degradation, this tripeptide is thought to signal fibroblasts to increase…
Safety considerations: Generally well tolerated; No significant adverse effects reported; Natural component of collagen — low allergenicity expected.
Reviewed by the PeptideAtlas Editorial Team.
| Amino-acid sequence | Gly-Pro-Hyp |
|---|---|
| Production method | synthetic |
| Anti-doping status | not-listed |
| US regulatory status | Cosmetic ingredient. Not FDA-regulated as a drug. |
Related peptides: Matrixyl, Matrixyl 3000, Snap-8.
No. Oral collagen supplements (hydrolyzed collagen) are digested into small peptides that enter the bloodstream and reach skin from the inside. Topical tripeptide-29 must penetrate the stratum corneum to reach dermal fibroblasts. The delivery routes and evidence bases are different. Oral collagen peptides have stronger clinical evidence for skin benefits.
Tripeptide-29 (Collagen Tripeptide) is a Gly-Pro-Hyp sequence identical to the most common repeating unit in type I collagen, used to stimulate fibroblast collagen production.
TRIPEPTIDE-29 has been studied for: Collagen synthesis signal, Skin structure support, Wrinkle reduction, Dermal matrix repair. Cosmetic peptide; most abundant collagen sequence motif.
The Gly-Pro-Hyp motif acts as a matrikine signal, detected by fibroblast integrin receptors as a collagen degradation fragment, triggering compensatory collagen I and III synthesis.