Snap-8 (acetyl octapeptide-3) is a cosmetic peptide developed by Lipotec as an extension of the hexapeptide Argireline (acetyl hexapeptide-3). It is an 8-amino acid peptide designed to inhibit SNARE complex formation at the neuromuscular junction, mimicking a botulinum toxin-like mechanism to reduce expression wrinkles. It adds two amino acids to the Argireline sequence, reportedly improving efficacy. Clinical evidence is very limited, consisting primarily of manufacturer-conducted studies.
4 vendors tracked by PeptideAtlas list Snap-8, priced from $23.00 to $45.00. The lowest price per milligram is $2.30/mg at All Peptides USA (10MG). 3 independent Janoshik purity tests cover Snap-8 across 3 vendors. Results range from 99.8% to 99.9%.
Category: Cosmetic Peptide. Evidence rating: F (anecdotal/unsupported).
Clinical status: Cosmetic ingredient. Manufacturer studies only; no independent clinical trials.
Snap-8 is a fragment analog of SNAP-25 (synaptosomal-associated protein of 25 kDa), one of the SNARE complex proteins required for neurotransmitter vesicle fusion and acetylcholine release at the neuromuscular junction. By competing with native SNAP-25, Snap-8 aims to partially inhibit vesicle…
Safety considerations: Generally well tolerated in cosmetic formulations; No significant adverse effects reported; Topical application limits systemic exposure.
Reviewed by the PeptideAtlas Editorial Team.
| Amino-acid sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp (Acetyl Octapeptide-3) |
|---|---|
| Production method | synthetic |
| Anti-doping status | not-listed |
| US regulatory status | Cosmetic ingredient. Not FDA-regulated as a drug. |
| Vendor | Size | Price | Price per mg |
|---|---|---|---|
| All Peptides USA | 10MG | $23.00 | $2.30/mg |
| Wholesale Peptide | 10mg | $28.04 | $2.80/mg |
| Arcane Peptides | 10MG | $35.00 | $3.50/mg |
| Protide Health | 10mg | $45.00 | $4.50/mg |
| Vendor | Best tested purity |
|---|---|
| Qingdao Sigma Chemical QSC | 99.9% |
| Eros Peptides | 99.8% |
Related peptides: Matrixyl, Matrixyl 3000, Palmitoyl Tripeptide-1.
Independent lab tests: Snap-8 purity test results.
No. While Snap-8 conceptually targets the same SNARE complex mechanism as botulinum toxin, topical application cannot achieve the same magnitude of neuromuscular inhibition as a direct injection. Snap-8 may provide modest cosmetic improvement for expression lines but is not a substitute for injectable botulinum toxin.
Snap-8 is an 8-amino acid peptide while Argireline is a 6-amino acid peptide. Both target the SNARE complex. Snap-8 has two additional amino acids that the manufacturer claims improve binding affinity. Both have limited independent clinical data.
SNAP-8 (Acetyl Octapeptide-3) is a cosmetic peptide researched as a 'Botox-like' wrinkle reducer that works by reducing muscle contraction at the molecular level.
SNAP-8 has been studied for: Anti-wrinkle research, Expression line reduction, Cosmetic enhancement. Botox-like peptide; topical cosmetic applications.
Inhibits SNARE complex formation, reducing neurotransmitter release and muscle contraction for expression line reduction.
Vendors with independent lab tests for it: Eros Peptides, Optima Chemical Supplies Inc.
Vendors stocking it: Amino Lair, Reta-Peptide, Zztai Peptide, All Peptides USA, Wholesale Peptide, BleauGenics, Treasure Coast Peptides, Protide Health, Bluewell Peptides, utherpeptide, Uther, Toronto Peptides, Arcane Peptides, Montreal Peptides, Pure Peptides UK, Advanced Peptides Australia, Wuhan Newtop Biotech, Suzhou Redgia Biotech RDG, Zhuzhou Yuyuan Biotechnology.
Coverage on this site: The Best Peptide Beauty Products for Firmer, Hydrated Skin, According to Dermatologists, FDA Eyes Lifting Restrictions on Cosmetic Peptides.
Independent lab results for Snap-8: Snap-8 — Independent Lab Test Results.