Matrixyl 3000 is a trademarked cosmetic ingredient (Sederma) consisting of a combination of two lipopeptides: palmitoyl tripeptide-1 (Pal-GHK) and palmitoyl tetrapeptide-7 (Pal-GQPR). The combination is designed to provide synergistic anti-aging effects — Pal-GHK stimulates collagen synthesis while Pal-GQPR reduces inflammation-driven aging (inflammaging). It is widely used in anti-aging skincare products. Clinical evidence is limited to manufacturer-sponsored studies and a small number of independent evaluations.
Category: Cosmetic Peptide. Evidence rating: F (anecdotal/unsupported).
Clinical status: Cosmetic ingredient. Limited published clinical data.
Palmitoyl tripeptide-1 (Pal-GHK) is a collagen-stimulating signal peptide that activates fibroblast collagen and glycosaminoglycan synthesis. Palmitoyl tetrapeptide-7 (Pal-GQPR) reduces IL-6 secretion, an inflammatory cytokine implicated in skin aging (inflammaging). The palmitoyl chains…
Safety considerations: Generally well tolerated in cosmetic formulations; Low irritation potential; No significant adverse effects reported.
Reviewed by the PeptideAtlas Editorial Team. Last reviewed: 2026-07-06.
Related peptides: Matrixyl, Snap-8, Palmitoyl Tripeptide-1.
Compare: Matrixyl 3000 vs Matrixyl, Matrixyl 3000 vs Snap-8, Matrixyl 3000 vs Palmitoyl Tripeptide-1.
They are different formulations with different mechanisms. Matrixyl 3000 combines a collagen-stimulating peptide with an anti-inflammatory peptide, while original Matrixyl (Pal-KTTKS) is a single peptide. There are no rigorous head-to-head comparisons. Both have limited independent clinical data.
Matrixyl 3000 is a trademarked cosmetic ingredient (Sederma) consisting of a combination of two lipopeptides: palmitoyl tripeptide-1 (Pal-GHK) and palmitoyl tetrapeptide-7 (Pal-GQPR). The combination is designed to provide synergistic anti-aging effects — Pal-GHK stimulates collagen synthesis while Pal-GQPR reduces inflammation-driven aging (inflammaging). It is widely used in anti-aging…
On the PeptideAtlas A–F scale, Matrixyl 3000 is rated F (Safety Concern). Safety concerns, misleading claims, or no credible basis
Cosmetic ingredient. Limited published clinical data.
Palmitoyl tripeptide-1 (Pal-GHK) is a collagen-stimulating signal peptide that activates fibroblast collagen and glycosaminoglycan synthesis. Palmitoyl tetrapeptide-7 (Pal-GQPR) reduces IL-6 secretion, an inflammatory cytokine implicated in skin aging (inflammaging). The palmitoyl chains facilitate skin penetration. The combination aims to both stimulate new collagen production and reduce the…