Sh-polypeptide-1 is the INCI (International Nomenclature of Cosmetic Ingredients) designation for recombinant human epidermal growth factor (rh-EGF) produced by bioengineering (typically in E. coli or yeast expression systems). The "sh" prefix indicates a synthetic human protein. It is functionally identical to natural EGF and is used in cosmetic skincare products for anti-aging and skin renewal. It differs from oligopeptide-1 primarily in nomenclature and regulatory classification rather than in biological activity. Clinical evidence specific to this designation is limited; much of the supporting data comes from EGF research generally.
Category: Cosmetic Peptide. Evidence rating: F (anecdotal/unsupported).
Clinical status: Cosmetic ingredient. Clinical data draws on general EGF research rather than studies specific to this INCI name.
Sh-polypeptide-1 is biologically identical to native human EGF and binds the same EGFR receptor, activating MAPK/ERK and PI3K/Akt signaling to promote keratinocyte and fibroblast proliferation, migration, and differentiation. The recombinant production process ensures consistent sequence identity…
Safety considerations: Same safety profile as EGF — generally well tolerated topically; No significant adverse effects reported in cosmetic use; Produced by bioengineering with high purity standards possible.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | recombinant |
|---|---|
| Anti-doping status | not-listed |
| US regulatory status | Cosmetic ingredient. Not FDA-regulated as a drug. |
Related peptides: Matrixyl, Matrixyl 3000, Snap-8.
Both are names for EGF in cosmetic nomenclature. Sh-polypeptide-1 specifically denotes recombinant human EGF (bioengineered). Oligopeptide-1 is a broader designation. In practice, both refer to the same 53-amino acid protein. Some regulatory frameworks distinguish between them based on production method.
Sh-polypeptide-1 is the INCI (International Nomenclature of Cosmetic Ingredients) designation for recombinant human epidermal growth factor (rh-EGF) produced by bioengineering (typically in E. coli or yeast expression systems). The "sh" prefix indicates a synthetic human protein. It is functionally identical to natural EGF and is used in cosmetic skincare products for anti-aging and skin…
On the PeptideAtlas A–F scale, Sh-Polypeptide-1 is rated F (Safety Concern). Safety concerns, misleading claims, or no credible basis
Cosmetic ingredient. Clinical data draws on general EGF research rather than studies specific to this INCI name.
Sh-polypeptide-1 is biologically identical to native human EGF and binds the same EGFR receptor, activating MAPK/ERK and PI3K/Akt signaling to promote keratinocyte and fibroblast proliferation, migration, and differentiation. The recombinant production process ensures consistent sequence identity with native EGF. In cosmetic applications, it aims to promote epidermal turnover, stimulate collagen…