Palmitoyl tripeptide-5 (marketed as Syn-Coll by DSM) is a lipopeptide designed to mimic the action of thrombospondin-1, a natural activator of TGF-beta. By activating TGF-beta signaling, it stimulates collagen synthesis in dermal fibroblasts. It is used in anti-aging cosmetic formulations. The evidence base is limited to manufacturer-sponsored studies and in vitro data; independent peer-reviewed clinical studies are scarce.
Category: Cosmetic Peptide. Evidence rating: F (anecdotal/unsupported).
Clinical status: Cosmetic ingredient. Manufacturer data only; no independent clinical trials.
Palmitoyl tripeptide-5 mimics a sequence from thrombospondin-1 (TSP-1), which naturally activates transforming growth factor beta (TGF-beta). TGF-beta is a key regulator of extracellular matrix production, stimulating fibroblasts to synthesize collagen I and collagen III. By activating TGF-beta…
Safety considerations: Generally well tolerated in cosmetic formulations; No significant adverse effects reported; Low irritation potential.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
| US regulatory status | Cosmetic ingredient. Not FDA-regulated as a drug. |
Related peptides: Matrixyl, Matrixyl 3000, Snap-8.
Unlike Matrixyl (which mimics a procollagen fragment) or GHK-based peptides, palmitoyl tripeptide-5 works upstream by activating TGF-beta signaling through a thrombospondin-1 mimetic mechanism. Whether this different approach translates to different clinical outcomes is unknown, as comparative studies do not exist.
Palmitoyl tripeptide-5 (marketed as Syn-Coll by DSM) is a lipopeptide designed to mimic the action of thrombospondin-1, a natural activator of TGF-beta. By activating TGF-beta signaling, it stimulates collagen synthesis in dermal fibroblasts. It is used in anti-aging cosmetic formulations. The evidence base is limited to manufacturer-sponsored studies and in vitro data; independent peer-reviewed…
On the PeptideAtlas A–F scale, Palmitoyl Tripeptide-5 is rated F (Safety Concern). Safety concerns, misleading claims, or no credible basis
Cosmetic ingredient. Manufacturer data only; no independent clinical trials.
Palmitoyl tripeptide-5 mimics a sequence from thrombospondin-1 (TSP-1), which naturally activates transforming growth factor beta (TGF-beta). TGF-beta is a key regulator of extracellular matrix production, stimulating fibroblasts to synthesize collagen I and collagen III. By activating TGF-beta through this mimetic pathway, Pal-tripeptide-5 aims to increase dermal collagen content. The palmitoyl…
Coverage on this site: Peptide Skincare: Botox-Like Results Without Injections, Palmitoyl Tripeptide: Multi-Benefit Peptide for Skin Care.