Copper tripeptide-1 (GHK-Cu) is the copper complex of the tripeptide glycyl-L-histidyl-L-lysine. Note: This entry focuses on the cosmetic/dermatological use of GHK-Cu. For comprehensive coverage of GHK-Cu as a wound healing and research peptide, see the dedicated GHK-Cu entry. Copper tripeptide-1 is used extensively in anti-aging skincare and hair care products. It has demonstrated wound healing, collagen-stimulating, and anti-inflammatory properties in published studies. Among cosmetic peptides, GHK-Cu has a relatively strong evidence base, including several controlled clinical studies.
Category: Cosmetic Peptide. Evidence rating: F (anecdotal/unsupported).
Clinical status: Cosmetic ingredient with clinical studies. Also studied for wound healing.
GHK-Cu delivers copper ions to skin cells while the GHK peptide acts as a signaling molecule. Copper is a cofactor for lysyl oxidase (collagen cross-linking), superoxide dismutase (antioxidant defense), and other enzymes essential for tissue maintenance. The GHK peptide activates genes involved in…
Safety considerations: Generally well tolerated topically; Mild irritation possible at higher concentrations; Rare allergic contact dermatitis.
Reviewed by the PeptideAtlas Editorial Team.
| Amino-acid sequence | Gly-His-Lys:Cu(II) |
|---|---|
| Production method | synthetic |
| Anti-doping status | not-listed |
| US regulatory status | Cosmetic ingredient. Not FDA-regulated as a drug for cosmetic claims. |
Related peptides: Matrixyl, Matrixyl 3000, Snap-8.
Yes. Copper tripeptide-1 is the INCI (International Nomenclature of Cosmetic Ingredients) name for GHK-Cu. They are the same molecule — the tripeptide glycyl-histidyl-lysine complexed with a copper(II) ion.
Caution is advised. GHK-Cu may not be stable at very low pH (such as with L-ascorbic acid serums), and there are theoretical interactions. Many dermatologists recommend using copper peptides and acids/retinoids at different times of day.
Copper tripeptide-1 (GHK-Cu) is the copper complex of the tripeptide glycyl-L-histidyl-L-lysine. Note: This entry focuses on the cosmetic/dermatological use of GHK-Cu. For comprehensive coverage of GHK-Cu as a wound healing and research peptide, see the dedicated GHK-Cu entry. Copper tripeptide-1 is used extensively in anti-aging skincare and hair care products. It has demonstrated wound…
On the PeptideAtlas A–F scale, Copper Tripeptide-1 is rated F (Safety Concern). Safety concerns, misleading claims, or no credible basis
Cosmetic ingredient with clinical studies. Also studied for wound healing.
Coverage on this site: Common Cosmetic Peptides: Copper, Carnosine, Glutathione, and More, IndexBox Lists US$4,000 UK Peptide Serum Report, No Findings, Copper Peptides Go Mainstream in Skin Care as GHK-Cu Leads the Field, Most Commonly Used Peptides in Cosmetics and Their Functions, The Best Peptide Beauty Products for Firmer, Hydrated Skin, According to Dermatologists, MOTS-c Peptide: Metabolism, Performance, and Stress Benefits.