Biotinoyl tripeptide-1 is a peptide consisting of the GHK (glycyl-histidyl-lysine) tripeptide conjugated to biotin (vitamin B7). It is used in hair care products, often as part of the Procapil complex (biotinoyl tripeptide-1 + apigenin + oleanolic acid). It is designed to strengthen hair and reduce hair loss by improving follicle anchoring and metabolism. The evidence base is limited to manufacturer-sponsored studies; independent clinical trials are scarce.
Category: Cosmetic Peptide. Evidence rating: F (anecdotal/unsupported).
Clinical status: Cosmetic ingredient. Limited published data, mostly as part of Procapil complex.
Biotinoyl tripeptide-1 combines two active moieties: the GHK tripeptide (which stimulates extracellular matrix production and tissue repair) and biotin (which is essential for keratin production and fatty acid synthesis in hair follicles). The conjugate is proposed to improve metabolic activity in…
Safety considerations: Generally well tolerated in topical hair products; No significant adverse effects reported; Biotin and GHK are both naturally occurring compounds with good safety profiles.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
| US regulatory status | Cosmetic ingredient. Not FDA-regulated as a drug. |
Related peptides: Matrixyl, Matrixyl 3000, Snap-8.
There is limited evidence, primarily from manufacturer studies of the Procapil complex. It may provide modest benefits for hair health, but it should not be considered a replacement for evidence-based hair loss treatments such as minoxidil or finasteride, which have robust clinical trial data.
Procapil is a trademarked cosmetic active complex containing three ingredients: biotinoyl tripeptide-1 (stimulates follicular matrix), apigenin (improves follicular blood flow), and oleanolic acid (inhibits 5-alpha reductase). Most clinical data for biotinoyl tripeptide-1 comes from studies of this complete complex.
Biotinoyl tripeptide-1 is a peptide consisting of the GHK (glycyl-histidyl-lysine) tripeptide conjugated to biotin (vitamin B7). It is used in hair care products, often as part of the Procapil complex (biotinoyl tripeptide-1 + apigenin + oleanolic acid). It is designed to strengthen hair and reduce hair loss by improving follicle anchoring and metabolism. The evidence base is limited to…
On the PeptideAtlas A–F scale, Biotinoyl Tripeptide-1 is rated F (Safety Concern). Safety concerns, misleading claims, or no credible basis
Cosmetic ingredient. Limited published data, mostly as part of Procapil complex.
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