Acetyl tetrapeptide-5 (marketed as Eyeseryl by Lipotec) is a cosmetic peptide designed to reduce under-eye puffiness (periorbital edema) and dark circles. It is proposed to work by reducing tissue water accumulation and improving microcirculation. It is widely used in eye creams and serums. The evidence base consists primarily of manufacturer studies; independent clinical data is very limited.
Category: Cosmetic Peptide. Evidence rating: F (anecdotal/unsupported).
Clinical status: Cosmetic ingredient. Manufacturer studies only.
Acetyl tetrapeptide-5 is proposed to reduce edema by decreasing vascular permeability and improving lymphatic drainage around the eyes. It may inhibit glycation of proteins in the extracellular matrix, helping maintain elasticity and fluid balance in periorbital tissue. The anti-edema mechanism is…
Safety considerations: Generally well tolerated in eye-area formulations; No significant adverse effects reported; Designed for the sensitive periorbital area.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
| US regulatory status | Cosmetic ingredient. Not FDA-regulated as a drug. |
Related peptides: Matrixyl, Matrixyl 3000, Snap-8.
Manufacturer data shows modest improvements in under-eye puffiness. However, there are no independent, peer-reviewed clinical trials confirming these findings. Under-eye puffiness has many causes (genetics, fluid retention, aging, allergies) and a topical peptide is unlikely to address all of them.
Acetyl tetrapeptide-5 (marketed as Eyeseryl by Lipotec) is a cosmetic peptide designed to reduce under-eye puffiness (periorbital edema) and dark circles. It is proposed to work by reducing tissue water accumulation and improving microcirculation. It is widely used in eye creams and serums. The evidence base consists primarily of manufacturer studies; independent clinical data is very limited.
On the PeptideAtlas A–F scale, Acetyl Tetrapeptide-5 is rated F (Safety Concern). Safety concerns, misleading claims, or no credible basis
Cosmetic ingredient. Manufacturer studies only.
Acetyl tetrapeptide-5 is proposed to reduce edema by decreasing vascular permeability and improving lymphatic drainage around the eyes. It may inhibit glycation of proteins in the extracellular matrix, helping maintain elasticity and fluid balance in periorbital tissue. The anti-edema mechanism is attributed to effects on capillary permeability, reducing fluid leakage into surrounding tissue.…
Coverage on this site: Peptide Skincare: Botox-Like Results Without Injections, Acetyl Tetrapeptide: Multifunctional Peptide for Skin and Hair Health.