A selective permeability barrier formed by tightly joined endothelial cells lining brain capillaries. Prevents most peptides from reaching brain tissue. Intranasal delivery, lipophilic modifications, or small peptide size can help bypass the BBB.
"Blood-Brain Barrier (BBB)" is filed under Cell Biology in the PeptideAtlas glossary, alongside 6 other terms in that group.
A phospholipid found almost exclusively in the inner mitochondrial membrane, essential for the function of respiratory chain complexes and ATP production. Cardiolipin damage is linked to aging and metabolic disease. The peptide SS-31 (Elamipretide) selectively binds cardiolipin to stabilize mitochondrial function.
The inward folds of the inner mitochondrial membrane where the electron transport chain and ATP synthase are located. Cristae structure determines mitochondrial efficiency. Cardiolipin stabilization by SS-31 helps maintain normal cristae architecture.
A cellular recycling process where damaged proteins and organelles are engulfed and degraded. Important for cellular maintenance and longevity. Fasting, AMPK activation, and certain peptides may promote autophagy.
More Cell Biology terms: Cardiolipin, Cristae, Autophagy, Apoptosis, Mitochondrial Biogenesis, Satellite Cells.