In a 3-month observational study of 25 Japanese adults with type 2 diabetes, oral semaglutide was associated with significant reductions in HbA1c, body weight, body fat percentage, total energy intake, and daily salt intake, alongside an increase in muscle mass percentage. Handgrip strength did not change significantly, and the macronutrient energy distribution remained unchanged.
Observational study — Prospective observational study. Population: Japanese adults with Type 2 diabetes newly initiated on oral semaglutide in clinical practice. Sample size: 25 participants. Follow-up: 3 months. Interventions: oral semaglutide.
A total of 25 participants were followed for 3 months. Significant reductions were seen in HbA1c, body weight, percent body fat, total energy intake, and daily salt intake (from 8.9 to 7.0 g/day). Percent muscle mass increased significantly, while handgrip strength did not change significantly. Macronutrient energy distribution was unchanged, but intakes of fats and oils, seasonings and spices, and sweets and snacks decreased significantly.
This paper provides real-world evidence on the effects of oral semaglutide on dietary intake and body composition in Japanese patients with type 2 diabetes, a population often underrepresented in trials. It does not establish long-term efficacy or safety, nor does it compare oral semaglutide with other GLP-1 receptor agonists or lifestyle interventions.
Peptide profiles: Semaglutide.
All indexed evidence: Semaglutide trials & papers.
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