Pal-AHK (Palmitoyl Tripeptide-3) is a lipopeptide combining a palmitoyl group with the AHK copper-binding tripeptide sequence. Researched primarily for hair follicle stimulation and scalp health, the palmitoyl group enhances skin/scalp penetration for topical delivery.
Category: Skin & Cosmetic. Evidence rating: D (animal/preclinical only).
Clinical status: Cosmetic ingredient. Limited clinical data for hair growth.
The palmitoyl group enhances skin penetration, delivering the AHK tripeptide sequence to hair follicles where it may stimulate dermal papilla cells and promote growth factor expression. The AHK sequence binds copper ions, delivering them to follicular tissue.
Safety considerations: Generally well-tolerated topically; Cosmetic-grade safety profile; Allergic reactions possible but uncommon.
Reviewed by the PeptideAtlas Editorial Team.
| Molecular weight | ~580 Da |
|---|---|
| Production method | synthetic |
| US regulatory status | Cosmetic ingredient. Not FDA-regulated as drug. |
Related peptides: GHK, Palmitoyl Dipeptide-6.
Both deliver copper-binding peptide sequences. Pal-AHK specifically targets hair follicles with its lipophilic palmitoyl group for enhanced scalp penetration, while GHK-Cu has broader wound healing and skin repair applications.
Pal-AHK (Palmitoyl Tripeptide-3) is a lipopeptide combining a palmitoyl group with the AHK copper-binding sequence, researched for hair follicle stimulation and scalp health.
PAL-AHK has been studied for: Hair follicle stimulation, Scalp health, Hair thickness, Growth factor activation. Lipopeptide for hair growth; enhanced-penetration form of AHK.
Palmitoyl group enhances skin penetration, delivering the AHK tripeptide sequence to hair follicles where it may stimulate dermal papilla cells and promote VEGF expression.
Coverage on this site: Pal-AHK's Role in Follicular Cell Growth and Apoptosis Reduction.