GHK is a naturally occurring tripeptide (Gly-His-Lys) that serves as the base form of GHK-Cu. Found in human plasma, saliva, and urine, its concentration declines with age. Researched for wound healing, tissue repair, and gene expression modulation related to tissue remodeling and collagen synthesis.
Category: Skin & Cosmetic. Evidence rating: C (early/mixed human evidence).
Clinical status: Research compound. GHK-Cu has more extensive research history. Cosmetic ingredient.
Modulates gene expression related to tissue remodeling, collagen synthesis, and wound healing. Resets gene expression of multiple genes toward a healthier pattern. When bound to copper (as GHK-Cu), also delivers copper ions essential for enzyme function in tissue repair processes.
Safety considerations: Generally regarded as safe in cosmetic concentrations; Naturally occurring in human body; Topical application well-tolerated.
Reviewed by the PeptideAtlas Editorial Team.
| Amino-acid sequence | Gly-His-Lys |
|---|---|
| Molecular weight | 340.4 Da |
| Production method | synthetic |
| US regulatory status | Cosmetic ingredient. Not FDA-approved as drug. Research compound. |
Related peptides: Pal-AHK, Palmitoyl Dipeptide-6.
Compare: GHK vs Pal-AHK.
GHK is the free tripeptide; GHK-Cu is the same peptide complexed with a copper ion. GHK-Cu is the more commonly researched and commercially available form, as copper binding enhances its biological activity.
GHK is a naturally occurring tripeptide that serves as the base form of GHK-Cu. It's researched for wound healing and tissue repair properties.
GHK has been studied for: Tissue repair, Wound healing, Skin health. Base form of GHK-Cu copper peptide.
Modulates gene expression related to tissue remodeling, collagen synthesis, and wound healing.
Coverage on this site: GHK-Cu Stability: Key Factors Researchers Should Know, GHK-Cu: Copper Peptide in Tissue Repair and Skin Research, Glow Blend: GHK-Cu, BPC-157 & TB-500 Peptide Research, GHK-Cu Peptide: Key Mechanisms and Research Findings.