Gonadorelin is a synthetic decapeptide identical to the naturally occurring gonadotropin-releasing hormone (GnRH) produced in the hypothalamus. It stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate testosterone production in men and ovulation in women. It is used clinically for diagnostic testing of pituitary function, and in pulsatile administration for certain infertility conditions. In the peptide community, it is commonly discussed as a complement to testosterone replacement therapy to maintain testicular function and fertility.
4 vendors tracked by PeptideAtlas list Gonadorelin, priced from $33.99 to $90.00. The lowest price per milligram is $6.80/mg at Wholesale Peptide (5mg).
Category: Reproductive / Hormonal. Evidence rating: A (strong human clinical data).
Clinical status: FDA-approved (Factrel for diagnostic use; Lutrepulse for pulsatile infertility treatment, now discontinued). Generic diagnostic formulation available.
Gonadorelin binds to GnRH receptors on gonadotrope cells in the anterior pituitary gland, stimulating release of LH and FSH. When administered in a pulsatile fashion (mimicking natural hypothalamic GnRH secretion every 60–120 minutes), it maintains or restores the physiological LH/FSH surge needed…
Research base: 561 registered clinical trials and 39 indexed publications reference Gonadorelin.
Safety considerations: Common: headache, flushing, nausea, dizziness, injection site reactions; Rare: facial/lip/tongue/throat swelling (allergic reaction); Injection site hardening with repeated SC administration.
Reviewed by the PeptideAtlas Editorial Team.
| Amino-acid sequence | pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 |
|---|---|
| Molecular weight | ~1182.4 g/mol |
| CAS number | 33515-09-2 |
| Half-life | ~2–4 minutes IV; ~40 minutes SC |
| Production method | synthetic |
| Anti-doping status | Prohibited in sport (WADA) |
| US regulatory status | FDA-approved (Factrel for pituitary diagnostic testing). Lutrepulse (pulsatile pump) discontinued but was previously approved. Available through compounding pharmacies. |
| Vendor | Size | Price | Price per mg |
|---|---|---|---|
| Wholesale Peptide | 5mg | $33.99 | $6.80/mg |
| Prime Source | 10mg | $90.00 | $9.00/mg |
| Pacific Peptide | 5mg | $75.00 | $15.00/mg |
| Colorado Research Peptides | 2mg | $40.00 | $20.00/mg |
Related peptides: Kisspeptin, Oxytocin, Vasopressin.
Gonadorelin stimulates your pituitary to produce LH naturally, while HCG mimics LH directly. Gonadorelin works "upstream" — it preserves the full hypothalamic-pituitary-gonadal axis. HCG bypasses the pituitary entirely. Both can maintain testicular function during TRT.
After the FDA reclassified HCG as a biologic in 2020, compounding pharmacies could no longer easily produce it. Some TRT clinics switched to gonadorelin as an alternative to maintain fertility and testicular size during testosterone therapy.
Pulsatile administration (every 60–120 min) increases LH/FSH and thus testosterone. But continuous (non-pulsatile) administration paradoxically suppresses LH/FSH by downregulating GnRH receptors — this is the same mechanism used in prostate cancer treatment with GnRH agonists.
Vendors stocking it: Zztai Peptide, Ultima Pharmaceuticals, Pacific Peptide, Wholesale Peptide, Colorado Research Peptides, bodypharm.me | Worldwide Shipping, Wuhan HongyouJie HYJ, Prime Source.
Coverage on this site: Women Report Pregnancies After Taking GLP-1 Weight-Loss Drugs, Intranasal Peptide Drugs: Development and Approved Products, GnRH3 Neuropeptide Regulates PGC Proliferation and Sex Differentiation in Zebrafish, Leuprolide Acetate's Key Role in Reproductive Disorders, Triptorelin: Synthetic GnRH Agonist for Hormone Research.