AOD-9604 is a modified fragment of human growth hormone (amino acids 177-191 plus an N-terminal tyrosine, Tyr-hGH(177-191)) developed at Monash University, Australia. It retains the lipolytic (fat-burning) properties of HGH while discarding the growth-promoting and diabetogenic effects. It underwent six randomized, double-blind, placebo-controlled human clinical trials for obesity in the early 2000s, showing modest but consistent fat loss (~5% body weight) with a side effect profile indistinguishable from placebo. The FDA granted it GRAS status for food use in 2014, though clinical development for obesity was discontinued.
38 vendors tracked by PeptideAtlas list AOD-9604, priced from $28.00 to $228. The lowest price per milligram is $2.20/mg at Supopeptide (50mg). 8 independent Janoshik purity tests cover AOD-9604 across 7 vendors. Results range from 39.0% to 99.7%.
Category: Metabolic / Fat Loss. Evidence rating: C (early/mixed human evidence).
Clinical status: Clinical development discontinued after Phase 2; GRAS status for food use
AOD-9604 (C78H123N23O23S2) works through a dual-action mechanism: it accelerates breakdown of stored fat (lipolysis) via cAMP signaling and enzymatic activation (stimulating hormone-sensitive lipase), while simultaneously blocking formation of new fat (lipogenesis). It stimulates lipolysis in a…
Research base: 0 registered clinical trials and 1 indexed publication reference AOD-9604.
Safety considerations: In extensive clinical trials, side effect profile was virtually indistinguishable from placebo; Mild injection site reactions (redness, pain, small welts) are the most common complaint; Mild headaches or flushing reported in small percentage of users.
Reviewed by the PeptideAtlas Editorial Team.
| Amino-acid sequence | hGH fragment 177-191 (Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe) |
|---|---|
| Molecular weight | ~1815.1 g/mol |
| CAS number | 221231-10-3 |
| Half-life | ~30 minutes |
| Bioavailability | FDA GRAS approval is for oral use as food ingredient; oral bioavailability as a peptide therapeutic is very low |
| Production method | synthetic |
| Anti-doping status | Prohibited in sport (WADA) |
| US regulatory status | Not FDA-approved as a drug. FDA granted GRAS status for food use (2014). Available as research chemical. |
| Vendor | Size | Price | Price per mg |
|---|---|---|---|
| Supopeptide | 50mg | $110 | $2.20/mg |
| PureRx Peptides | 10mg | $28.00 | $2.80/mg |
| Archer Peptides | 10MG | $40.00 | $4.00/mg |
| All Peptides USA | 10MG | $49.00 | $4.90/mg |
| BioPep Store | 5.23mg | $36.00 | $6.88/mg |
| Particle Peptides | 5mg | $35.88 | $7.18/mg |
| Athena Peptides | 5MG | $39.00 | $7.80/mg |
| Bio Pepz | 5mg | $40.00 | $8.00/mg |
| Huaian Hanyou Peptide | 5mg | $40.00 | $8.00/mg |
| Guangzhou Jeep Biotechnology JEEP | 5mg | $40.00 | $8.00/mg |
| China Peptides Supplier | 5mg | $41.00 | $8.20/mg |
| PureGenix Peptides | 10mg | $85.00 | $8.50/mg |
| Onyx Research | 5mg | $45.00 | $9.00/mg |
| Honest Peptide | 10mg | $90.00 | $9.00/mg |
| Arcane Peptides | 5mg | $45.00 | $9.00/mg |
| Purus Peptides | 5mg | $49.00 | $9.80/mg |
| Pharma Grade Peptides | 10MG | $99.99 | $10.00/mg |
| US Peptides | 5mg | $50.00 | $10.00/mg |
| Precision Peptide Co | 5mg | $53.50 | $10.70/mg |
| Oasis Peptides | 5mg | $54.50 | $10.90/mg |
| Blue Line Research | 5mg | $55.00 | $11.00/mg |
| Ameano Peptides | 5mg | $58.00 | $11.60/mg |
| Compound Purity | 5mg | $58.00 | $11.60/mg |
| Triantex | 5mg | $59.99 | $12.00/mg |
| ZestyRat Research | 5mg | $59.99 | $12.00/mg |
| Vendor | Best tested purity |
|---|---|
| MOB Peptides | 99.7% |
| Peptide Crafters | 99.7% |
| HPR | 99.2% |
| Optima Chemical Supply, Inc. | 99.1% |
| Pink Pony Peptides | 99.0% |
| Panda Peptides LLC | 39.0% |
Related peptides: 5-Amino-1MQ.
Independent lab tests: AOD-9604 purity test results.
Human clinical trials showed modest but consistent fat loss (~5% body weight) compared to placebo with an excellent safety profile. However, the effect was not large enough for the developer to pursue FDA approval. It was discontinued as a pharmaceutical obesity candidate.
No. AOD-9604 is a small 16-amino-acid fragment from the C-terminus (positions 177-191) of the 191-amino-acid HGH molecule. It retains fat-burning properties but lacks the growth, IGF-1-stimulating, and diabetogenic effects of full HGH.
Insulin blocks AOD-9604's mechanism. Taking it on an empty stomach (waiting 30-60 minutes before eating) allows the peptide to spike in the bloodstream and trigger lipolysis while insulin remains at baseline fasting levels.
In 2014, the FDA granted AOD-9604 Generally Recognized As Safe (GRAS) status for use as a food additive, which attests to its non-toxic nature. This is separate from drug approval.
Yes. WADA prohibits all growth hormone fragments and related peptides not approved for therapeutic use.
Vendors with independent lab tests for it: Pink Pony Peptides, HPR, Peptide Crafters.
Vendors stocking it: Direct Peptides UK, Limitless Life Nootropics, Polar Peptides, NUPEPS Peptides, Amino Lair, Bio Pepz, Oasis Peptides, Zztai Peptide, Pura Peptides, All Peptides USA, China Peptides Supplier, Biomax Research, Ameano Peptides, Prime Lab Peptides, Flycn Peptide, Pacific Peptide, Ascension Peptides, Onyx Research, Triantex, BioPep Store, BleauGenics, Compound Purity, Purus Peptides, Peplogix Peptides, Modern Peptides, HJ Peptide, Blue Line Research, Kyin Peptide, Lunivo Peptide, Supopeptide, Treasure Coast Peptides, PureGenix Peptides, Anglo Peptides, BioPure Peptides, Archer Peptides, ZestyRat Research, Athena Peptides, PureRx Peptides, Catalyst Peptides, Tong Peptide.
Coverage on this site: Why Research Peptides Vary in Price: Manufacturing Complexity Breakdown.
Independent lab results for AOD-9604: Aod-9604 — Independent Lab Test Results.