5-Amino-1MQ is a small molecule (not technically a peptide) that selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue of obese individuals. NNMT degrades the NAD+ precursor SAM, linking it to metabolic dysfunction. By blocking NNMT, 5-Amino-1MQ increases intracellular NAD+ and SAM levels, theoretically boosting fat cell energy expenditure and shrinking adipocytes. All data is preclinical.
31 vendors tracked by PeptideAtlas list 5-Amino-1MQ, priced from $23.00 to $300. The lowest price per milligram is $0.900/mg at Peptide Importer (50mg). 8 independent Janoshik purity tests cover 5-Amino-1MQ across 5 vendors.
Category: Metabolic / Fat Loss. Evidence rating: D (animal/preclinical only).
Clinical status: Preclinical only. No IND filed. No human clinical trials registered as of 2026.
Selectively inhibits NNMT, an enzyme highly expressed in white adipose tissue that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor. NNMT inhibition increases intracellular NAD+ and SAM concentrations. In diet-induced obese mice, NNMT inhibitors reduced…
Safety considerations: No human safety data available; In mouse studies, no obvious toxicity at effective doses over 10-day treatment periods; Does not cross the blood-brain barrier in animal models.
Reviewed by the PeptideAtlas Editorial Team.
| Molecular formula | C10H12N2O |
|---|---|
| Molecular weight | ~173.21 g/mol |
| Half-life | Unknown in humans; estimated hours based on animal PK |
| Bioavailability | Oral bioavailability demonstrated in mice |
| Production method | synthetic |
| Anti-doping status | not-listed |
| Vendor | Size | Price | Price per mg |
|---|---|---|---|
| Peptide Importer | 50mg | $45.00 | $0.900/mg |
| Petratide Science | 50mg | $54.95 | $1.10/mg |
| Bio Pepz | 50mg | $55.00 | $1.10/mg |
| All Peptides USA | 50MG | $55.00 | $1.10/mg |
| US Peptide Co | 50 mg | $59.99 | $1.20/mg |
| Mammoth Muscle Peptides | 50mg | $60.00 | $1.20/mg |
| Red Fox Peptides | 50 mg | $65.00 | $1.30/mg |
| Ameano Peptides | 50mg | $68.00 | $1.36/mg |
| VitalCell Peptides | 50mg | $69.99 | $1.40/mg |
| Athena Peptides | 50MG | $75.00 | $1.50/mg |
| Peak Peptides | 50mg | $85.00 | $1.70/mg |
| Great Northern Peptides | 50mg | $85.00 | $1.70/mg |
| Evolve BioPep | 50mg | $100 | $2.00/mg |
| Bioscience Peptides | 50mg | $115 | $2.30/mg |
| Buy Peptides Australia | 50 mg | $120 | $2.40/mg |
| Red Leaf Peptides | 50mg | $130 | $2.60/mg |
| Steady Meds | 10mg | $30.00 | $3.00/mg |
| Lab Trust Peptides | 50mg | $190 | $3.80/mg |
| Peplogix Peptides | 50.25mg | $200 | $3.98/mg |
| Growth Guys | 10mg | $40.00 | $4.00/mg |
| The Peptide Labs | 10MG | $40.00 | $4.00/mg |
| Wholesale Peptide | 10mg | $42.49 | $4.25/mg |
| Amino Nova | 10mg | $46.00 | $4.60/mg |
| SwissChems | 50mg | $249 | $4.98/mg |
| Fusion Peptides | 10 mg | $50.00 | $5.00/mg |
| Vendor | Best tested purity |
|---|
Related peptides: AOD-9604.
Independent lab tests: 5-Amino-1MQ purity test results.
No. It is a small molecule (quinolinium derivative) with a molecular weight of ~173 g/mol. It is commonly sold by peptide vendors and discussed in peptide communities, which creates confusion.
In community protocols, it is taken orally as a capsule, typically 50-150mg per day. These dosages are extrapolated from animal studies and have no human clinical validation.
5-Amino-1MQ is an NNMT (nicotinamide N-methyltransferase) inhibitor being researched for its potential effects on fat metabolism and cellular energy regulation. It represents an emerging target in metabolic research.
5-AMINO-1MQ has been studied for: Fat metabolism support, Metabolic regulation, Anti-aging potential. NNMT inhibitor; emerging fat metabolism target.
Inhibits NNMT enzyme, which plays a role in energy metabolism and fat storage. Research suggests this may help regulate adipose tissue metabolism and improve metabolic function.
Vendors with independent lab tests for it: Peptide Gurus, Eros Peptides.
Vendors stocking it: SwissChems, Limitless Life Nootropics, Polar Peptides, Red Leaf Peptides, OP Labs, Uniting Wellness, Bio Pepz, Oasis Peptides, Zztai Peptide, Evolve BioPep, Nexaph, ZePeptide, Steady Meds, Pura Peptides, Peptide Origin, All Peptides USA, Mia Peptide, Biomax Research, NovaPeptide, Ameano Peptides, Fusion Peptides, Pacific Peptide, Mammoth Muscle Peptides, Lab Rat Peptide, Ascension Peptides, Compound Sciences, Choice Peps, Genetic Peptides, Wholesale Peptide, Peplogix Peptides, Petratide Science, Modern Peptides, Legendary Peptides, Lab Trust Peptides, US Peptide Co, Bioscience Peptides, Anglo Peptides, Amino Nova, Great Lakes Peptides, ZestyRat Research.
Coverage on this site: Anti-Aging Peptides: Research Compounds for Metabolism, Muscle, and Tissue Health.
Independent lab results for 5-Amino-1MQ: 5-Amino-1MQ — Independent Lab Test Results.