5-Amino-1MQ is a small molecule (not technically a peptide) that selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in adipose tissue of obese individuals. NNMT degrades the NAD+ precursor SAM, linking it to metabolic dysfunction. By blocking NNMT, 5-Amino-1MQ increases intracellular NAD+ and SAM levels, theoretically boosting fat cell energy expenditure and shrinking adipocytes. All data is preclinical.
Category: Metabolic / Fat Loss. Evidence rating: D (animal/preclinical only).
Clinical status: Preclinical only. No IND filed. No human clinical trials registered as of 2026.
Selectively inhibits NNMT, an enzyme highly expressed in white adipose tissue that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor. NNMT inhibition increases intracellular NAD+ and SAM concentrations. In diet-induced obese mice, NNMT inhibitors reduced…
Safety considerations: No human safety data available; In mouse studies, no obvious toxicity at effective doses over 10-day treatment periods; Does not cross the blood-brain barrier in animal models.
Reviewed by the PeptideAtlas Editorial Team. Last reviewed: 2026-07-06.
Related peptides: AOD-9604.
Compare: 5-Amino-1MQ vs AOD-9604.
No. It is a small molecule (quinolinium derivative) with a molecular weight of ~173 g/mol. It is commonly sold by peptide vendors and discussed in peptide communities, which creates confusion.
In community protocols, it is taken orally as a capsule, typically 50-150mg per day. These dosages are extrapolated from animal studies and have no human clinical validation.
5-Amino-1MQ is an NNMT (nicotinamide N-methyltransferase) inhibitor being researched for its potential effects on fat metabolism and cellular energy regulation. It represents an emerging target in metabolic research.
5-AMINO-1MQ has been studied for: Fat metabolism support, Metabolic regulation, Anti-aging potential. NNMT inhibitor; emerging fat metabolism target.
Inhibits NNMT enzyme, which plays a role in energy metabolism and fat storage. Research suggests this may help regulate adipose tissue metabolism and improve metabolic function.