Toxic substances (lipopolysaccharides) released from the cell walls of gram-negative bacteria. Endotoxin testing (LAL test) is important for injectable peptide quality.
"Endotoxin" is filed under Quality in the PeptideAtlas glossary, alongside 12 other terms in that group.
The term applies directly to 1 compound profile here: LL-37 (evidence D). Each profile states the strength of the human evidence rather than only what the compound is claimed to do.
1 other glossary entry refer to this term in their own definition, which is usually the fastest way to see how it is used in practice.
A test using horseshoe crab blood extract to detect bacterial endotoxin contamination in injectable products. A passing LAL result on a COA indicates endotoxin levels are below the safety threshold.
A document from a laboratory (ideally third-party) that certifies the identity, purity, potency, and quality of a substance. Essential for verifying research peptide quality.
An analytical technique used to separate, identify, and quantify components in a mixture. Used in COAs to determine peptide purity percentage.
An analytical technique that measures the mass-to-charge ratio of molecules. Used in COAs to confirm peptide identity and molecular weight.
Compounds where this applies: LL-37.
Terms that reference this one: LAL Test (Limulus Amebocyte Lysate).
More Quality terms: Certificate of Analysis (COA), HPLC (High-Performance Liquid Chromatography), Mass Spectrometry (MS), Purity, cGMP (Current Good Manufacturing Practice), CAS Number, INCI Name, Amino Acid Analysis (AAA), LAL Test (Limulus Amebocyte Lysate), Sterility Testing, Degradation Product, Third-Party Testing.