A peptide design strategy where the amino acid sequence is reversed and D-amino acids replace L-amino acids. This preserves side-chain topology while dramatically increasing resistance to enzymatic degradation. FOXO4-DRI uses this approach.
"D-Retro-Inverso" is filed under Basics in the PeptideAtlas glossary, alongside 12 other terms in that group.
The building blocks of peptides and proteins. There are 20 standard amino acids that combine in various sequences to form peptides.
A short chain of amino acids (typically 2-50 amino acids) linked by peptide bonds. Shorter than proteins but with diverse biological activities.
The chemical bond formed between two amino acids when the carboxyl group of one reacts with the amino group of another, releasing water.
More Basics terms: Amino Acid, Peptide, Peptide Bond, Sequence, Analogue, Bioregulator, Neuropeptide, Signaling Peptide, Cyclization, PEGylation, Acylation, DAC (Drug Affinity Complex).