Testagen (Lys-Glu-Asp-Gly, KEDG) is a synthetic tetrapeptide (MW ~447.4 g/mol) from the Khavinson bioregulatory peptide family, designed as a testicular-specific bioregulator. It is proposed to restore Leydig cell function and testosterone production in aging males. Published primarily in Russian biogerontology literature.
1 independent Janoshik purity test cover Testagen across 1 vendor.
Category: Hormonal / Anti-Aging. Evidence rating: D (animal/preclinical only).
Clinical status: Russian clinical studies in elderly men. Not validated in Western trials.
Testagen is proposed to modulate gene expression in Leydig cells, restoring expression of steroidogenic enzymes (StAR, CYP11A1, CYP17A1) that decline with aging. In animal models, it reportedly increased testosterone production and improved spermatogenesis in aged rats. The mechanism follows the…
Safety considerations: Reported as well-tolerated in Russian clinical use; No serious adverse events reported; Simple tetrapeptide with expected low toxicity.
Reviewed by the PeptideAtlas Editorial Team.
| Amino-acid sequence | Lys-Glu-Asp-Gly (KEDG) |
|---|---|
| Molecular weight | ~447.4 g/mol |
| Half-life | ~20-40 minutes |
| Production method | synthetic |
| Anti-doping status | not-listed |
| US regulatory status | Research peptide. Not FDA-approved. |
| Vendor | Best tested purity |
|---|---|
| Peptide Gurus | 99.9% |
Related peptides: Prostamax.
No. Testagen is an experimental research peptide with limited evidence. It should not replace physician-supervised testosterone replacement therapy in men with diagnosed hypogonadism.
Testagen is a synthetic peptide bioregulator researched for its potential effects on testicular function and testosterone support as part of anti-aging protocols.
TESTAGEN has been studied for: Testosterone support, Anti-aging, Hormone optimization. Niche hormone support peptide.
Peptide bioregulator that may support testicular tissue and natural testosterone production.