Pancragen (Lys-Glu-Asp-Trp, KEDW) is a synthetic tetrapeptide (MW ~562.6 g/mol) from the Khavinson bioregulatory peptide family, designed as a pancreas-specific bioregulator. It is proposed to restore beta-cell function, improve insulin secretion, and normalize glucose metabolism in aging or metabolic disease. Published primarily in Russian biogerontology literature.
Category: Metabolic / Anti-Aging. Evidence rating: D (animal/preclinical only).
Clinical status: Russian clinical studies in patients with metabolic syndrome and type 2 diabetes. Not validated in Western trials.
Pancragen is proposed to interact with DNA regulatory sequences in pancreatic cells, particularly beta-cells, modulating expression of genes involved in insulin synthesis, glucose sensing, and beta-cell survival. In animal models of diabetes and aging, it reportedly improved glucose tolerance and…
Safety considerations: Reported as well-tolerated; No serious adverse events in published literature; Monitor blood glucose when used alongside antidiabetic medications.
Reviewed by the PeptideAtlas Editorial Team.
| Amino-acid sequence | Lys-Glu-Asp-Trp (KEDW) |
|---|---|
| Molecular weight | ~562.6 g/mol |
| Half-life | ~20-40 minutes |
| Production method | synthetic |
| Anti-doping status | not-listed |
| US regulatory status | Research peptide. Not FDA-approved. |
No. Pancragen is an experimental research peptide with limited evidence. It should never replace prescribed diabetes medications. If you have diabetes, continue working with your endocrinologist.
Pancragen is a Khavinson bioregulator tetrapeptide researched for pancreatic tissue support and beta-cell function, with potential applications in metabolic health and glucose regulation.
PANCRAGEN has been studied for: Pancreatic tissue support, Beta-cell function, Glucose metabolism, Age-related metabolic support. Khavinson bioregulator; pancreas/metabolic focus.
Tetrapeptide bioregulator that may interact with gene promoter regions in pancreatic cells, modulating expression of proteins involved in insulin secretion and beta-cell maintenance.