OS-01 is a proprietary peptide developed by OneSkin that targets cellular senescence in skin cells. It was identified through a high-throughput screen of peptide libraries for senolytic/senomorphic activity. Used in the OneSkin topical product line.
Category: Anti-Aging / Cosmetic. Evidence rating: D (animal/preclinical only).
Clinical status: Cosmetic product (OneSkin)
Reduces senescent cell burden in skin tissue and decreases senescence-associated secretory phenotype (SASP) factors. Improves epidermal barrier function and reduces skin biological age as measured by molecular markers.
Safety considerations: Well-tolerated in available studies.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
It has senomorphic properties (reducing SASP) and may have some senolytic activity (clearing senescent cells). The company describes it as targeting cellular senescence broadly.
OS-01 is a proprietary peptide developed by OneSkin that targets cellular senescence in skin cells. It was identified through a high-throughput screen of peptide libraries for senolytic/senomorphic activity. Used in the OneSkin topical product line.
On the PeptideAtlas A–F scale, OS-01 (OneSkin Peptide) is rated D (Preclinical Only). Mostly animal or preclinical evidence
Cosmetic product (OneSkin)
Reduces senescent cell burden in skin tissue and decreases senescence-associated secretory phenotype (SASP) factors. Improves epidermal barrier function and reduces skin biological age as measured by molecular markers.