NAD+ is a fundamental coenzyme present in all living cells that serves as a critical electron carrier in metabolic reactions and a substrate for enzymes including sirtuins, PARPs, and CD38. NAD+ levels decline approximately 50% between ages 40 and 60. While not a peptide, NAD+ and its precursors (NMN, NR) are frequently discussed in peptide communities. IV NAD+ infusions are popular at anti-aging clinics, though large-scale human efficacy trials are limited.
46 vendors tracked by PeptideAtlas list NAD+ (Nicotinamide Adenine Dinucleotide), priced from $29.00 to $207. The lowest price per milligram is $0.033/mg at Peplogix Peptides (4500mg). 21 independent Janoshik purity tests cover NAD+ (Nicotinamide Adenine Dinucleotide) across 20 vendors.
Category: Anti-Aging / Telomere. Evidence rating: C (early/mixed human evidence).
Clinical status: NAD+ IV: used clinically at anti-aging and addiction clinics; no FDA approval. NMN: Phase I/II human trials completed (Yoshino et al., Science 2021). NR: multiple human trials completed.
Functions as: (1) an electron carrier in glycolysis, TCA cycle, and oxidative phosphorylation; (2) a substrate for sirtuins (SIRT1-7), which regulate gene expression, DNA repair, and metabolism; (3) a substrate for PARPs, which repair DNA damage; (4) a substrate for CD38/CD157, involved in calcium…
Safety considerations: IV NAD+: commonly causes flushing, nausea, chest tightness, abdominal cramping during infusion — dose-rate dependent; Rare tachycardia and blood pressure changes during IV infusion; Oral NMN and NR are generally well-tolerated at doses up to 1200mg/day.
Reviewed by the PeptideAtlas Editorial Team.
| Molecular formula | C21H27N7O14P2 |
|---|---|
| Molecular weight | 663.43 g/mol |
| Half-life | ~30 minutes (IV plasma); intracellular NAD+ turnover ~6-10 hours |
| Bioavailability | ~100% IV; oral NAD+ <5%; NMN and NR are oral precursors |
| Production method | synthetic |
| Anti-doping status | not-prohibited |
| Vendor | Size | Price | Price per mg |
|---|---|---|---|
| Peplogix Peptides | 4500mg | $150 | $0.033/mg |
| Domestic Peps | 1000mg | $45.00 | $0.045/mg |
| Archer Peptides | 500MG | $29.00 | $0.058/mg |
| Choice Peps | 1000MG | $59.00 | $0.059/mg |
| Petratide Science | 1000mg | $64.95 | $0.065/mg |
| Peptide Labs | 750mg | $49.99 | $0.067/mg |
| Great Lakes Peptides | 1000mg | $70.00 | $0.070/mg |
| Kitsune Compounds | 500mg | $35.99 | $0.072/mg |
| Sigma Peptides | 500MG | $39.99 | $0.080/mg |
| Prospera Peptides | 500mg | $40.00 | $0.080/mg |
| PureRx Peptides | 1000mg | $80.00 | $0.080/mg |
| Great Northern Peptides | 1000mg | $80.00 | $0.080/mg |
| All Peptides USA | 500MG | $41.00 | $0.082/mg |
| Growth Guys | 350mg | $30.00 | $0.086/mg |
| US Peptide Co | 500mg | $43.99 | $0.088/mg |
| Athena Peptides | 1000MG | $89.00 | $0.089/mg |
| Evolve BioPep | 500mg | $45.00 | $0.090/mg |
| Peak Peptides | 1000mg | $90.00 | $0.090/mg |
| The Peptide Labs | 500MG | $45.00 | $0.090/mg |
| Panda Peptides | 500mg | $49.99 | $0.100/mg |
| Orbitrex Peptides | 500mg | $49.99 | $0.100/mg |
| Legendary Peptides | 500mg | $54.00 | $0.108/mg |
| Onyx Research | 500mg | $55.00 | $0.110/mg |
| Colorado Research Peptides | 500mg | $55.00 | $0.110/mg |
| Pulse Research Expansion | 500mg | $59.99 | $0.120/mg |
| Vendor | Best tested purity |
|---|
Related peptides: Epithalon.
While NAD+ is a coenzyme (not a peptide), it targets many of the same aging and metabolic pathways. Many peptide vendors also sell NAD+ and its precursors.
Each has different pharmacokinetics. IV provides immediate but transient elevation. Oral NMN and NR raise intracellular NAD+ through the salvage pathway with slower onset but potentially more sustained effects. No head-to-head trial has compared clinical outcomes.
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme critical for cellular energy production, DNA repair, and longevity pathways. Injectable forms are available from peptide vendors, bypassing oral bioavailability limitations.
NAD+ has been studied for: Cellular energy production, DNA repair support, Anti-aging potential, Metabolic regulation. Not a peptide; coenzyme. Available in 500mg and 1000mg injectable formulations from peptide vendors.
Essential coenzyme for mitochondrial function, sirtuin activation, and PARP-mediated DNA repair. Levels decline significantly with age.
Vendors with independent lab tests for it: Polaris Peptides, Penguin Peptides, XL Peptides, Pink Pony Peptides, Optima Chemical Supplies Inc.
Independent lab results for NAD+ (Nicotinamide Adenine Dinucleotide): Nad+ 500mg — Independent Lab Test Results, Nad+ — Independent Lab Test Results.