N-Acetyl Epithalon Amidate is a chemically modified version of epithalon (Ala-Glu-Asp-Gly) with N-terminal acetylation and C-terminal amidation. These modifications protect against enzymatic degradation, potentially improving half-life and bioavailability.
Category: Anti-Aging / Research. Evidence rating: D (animal/preclinical only).
Clinical status: Research-only
Same proposed mechanism as epithalon — telomerase activation and pineal gland function support. The N-acetyl and C-amide modifications protect the peptide termini from aminopeptidase and carboxypeptidase degradation, extending half-life.
Safety considerations: No specific safety data for this modified form.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
The terminal modifications should improve metabolic stability based on peptide chemistry, but no head-to-head studies exist. The base compound epithalon itself has limited evidence outside Russian literature.
N-Acetyl Epithalon Amidate is a chemically modified version of epithalon (Ala-Glu-Asp-Gly) with N-terminal acetylation and C-terminal amidation. These modifications protect against enzymatic degradation, potentially improving half-life and bioavailability.
On the PeptideAtlas A–F scale, N-Acetyl Epithalon Amidate is rated D (Preclinical Only). Mostly animal or preclinical evidence
Research-only
Same proposed mechanism as epithalon — telomerase activation and pineal gland function support. The N-acetyl and C-amide modifications protect the peptide termini from aminopeptidase and carboxypeptidase degradation, extending half-life.