Livagen (Lys-Glu-Asp-Ala, KEDA) is a synthetic tetrapeptide (MW ~432.5 g/mol) developed by Khavinson as a liver-specific bioregulatory peptide. It is proposed to decondense heterochromatin in hepatocytes, reactivating genes silenced during aging and restoring hepatic function. Published studies show effects on chromatin structure and gene expression in aged liver tissue. Clinical evidence is limited to Russian publications.
Category: Hepatic / Anti-Aging. Evidence rating: D (animal/preclinical only).
Clinical status: Published in Russian biogerontology literature. Limited Western peer review.
Livagen is proposed to penetrate hepatocyte nuclei and interact with specific heterochromatin regions that become condensed (silenced) during aging. By binding complementary DNA sequences in liver-specific gene promoters, it is claimed to decondense chromatin, reactivate gene transcription, and…
Safety considerations: Reported as well-tolerated in animal studies and limited clinical use; No serious adverse events reported; Simple tetrapeptide structure suggests low toxicity.
Reviewed by the PeptideAtlas Editorial Team.
| Amino-acid sequence | Lys-Glu-Asp-Ala (KEDA) |
|---|---|
| Molecular weight | ~432.5 g/mol |
| Half-life | ~20-40 minutes |
| Production method | synthetic |
| Anti-doping status | not-listed |
| US regulatory status | Research peptide. Not FDA-approved. |
According to Khavinson theory, Livagen reactivates genes in liver cells that become silenced with aging due to chromatin condensation. By decondensing heterochromatin, it theoretically restores youthful gene expression patterns. This is supported by electron microscopy in animals but not validated in human trials.
Livagen is a Khavinson bioregulator tetrapeptide (Lys-Glu-Asp-Ala) researched for hepatic (liver) tissue support and chromatin decondensation in hepatocytes.
LIVAGEN has been studied for: Liver tissue support, Hepatocyte function, Chromatin remodeling, Age-related liver support. Khavinson bioregulator; liver/hepatic tissue focus.
Tetrapeptide bioregulator that promotes chromatin decondensation in liver cells, potentially reactivating silenced genes involved in hepatocyte function and tissue repair.