GHK is a naturally occurring tripeptide first isolated from human plasma. It declines significantly with age. Even without copper complexation, GHK demonstrates gene-regulatory activity affecting over 4,000 genes related to tissue repair, immune function, and anti-inflammatory responses.
1 independent Janoshik purity test cover GHK (Glycyl-Histidyl-Lysine) across 1 vendor.
Category: Regenerative / Research. Evidence rating: C (early/mixed human evidence).
Clinical status: Research compound / Cosmetic ingredient
GHK modulates expression of over 4,000 human genes. It promotes collagen and decorin synthesis, regulates anti-inflammatory cytokines, and attracts stem cells to injury sites. It activates tissue remodeling pathways through multiple signaling cascades including TGF-beta and BMP pathways.
Safety considerations: Well-tolerated in available studies; Naturally present in human plasma.
Reviewed by the PeptideAtlas Editorial Team.
| Production method | synthetic |
|---|---|
| Anti-doping status | not-listed |
| Vendor | Best tested purity |
|---|---|
| Polaris Peptides | 99.8% |
GHK alone can chelate copper from the body. In some formulations, the non-copper form is preferred. GHK-Cu provides copper directly, which may be more efficient for certain applications.
GHK is a naturally occurring tripeptide first isolated from human plasma. It declines significantly with age. Even without copper complexation, GHK demonstrates gene-regulatory activity affecting over 4,000 genes related to tissue repair, immune function, and anti-inflammatory responses.
On the PeptideAtlas A–F scale, GHK (Glycyl-Histidyl-Lysine) is rated C (Early Evidence). Early human evidence, limited trials, or mixed findings
Research compound / Cosmetic ingredient
GHK modulates expression of over 4,000 human genes. It promotes collagen and decorin synthesis, regulates anti-inflammatory cytokines, and attracts stem cells to injury sites. It activates tissue remodeling pathways through multiple signaling cascades including TGF-beta and BMP pathways.
Coverage on this site: GHK-Cu Stability: Key Factors Researchers Should Know, GHK-Cu: Copper Peptide in Tissue Repair and Skin Research, Glow Blend: GHK-Cu, BPC-157 & TB-500 Peptide Research, GHK-Cu Peptide: Key Mechanisms and Research Findings.